稳心颗粒联合比索洛尔治疗老年阵发性心房颤动的临床疗效观察

目的观察稳心颗粒联合比索洛尔治疗老年阵发性心房颤动患者的临床疗效。方法选择102例老年阵发性房颤患者，随机分为两组。一组为对照组，男性38例，女性12例，年龄61-86岁，在常规治疗原发病的基础上给予比索洛尔1．25mg，每日2次，口服，作为起始剂量。另一组为观察组，男性36例，女性16例，年龄62-88岁，在对照组药物治疗基础上加用稳心颗粒9g，每日3次，口服。疗效不佳时两组均将比索洛尔逐渐加至5mg，每日1次，口服。观察治疗前后两组患者每周房颤发作次数、持续时间及服药后的临床疗效，共观察4周。结果药物治疗后两组患者每周房颤发作次数、持续时间均较治疗前明显减少，差异有统计学意义（P〈0．01），且观察组较对照组变化明显，差异有统计学意义（P〈O．05）；临床总有效率观察组高于对照组，差异有统计学意义（P〈O．05）。结论稳心颗粒治疗老年阵发性房颤有效，联合比索洛尔治疗，疗效优于单用比索洛尔。

Effects of wenxinkeli and bisoprolol in senile patients with paroxysmal atrial fibrillation

Objective To observe the clinical efficacy of combination of werLxinkeli and bisoprolol on treating paroxysmal atrial fibrillation in senile patients. Methods Selected 102 cases of senile patients with parox- ysmal atrial fibriUation, and divided into two groups randomly： Control group （38 males and 12 females, aged from 61 to 86 years old） was treated with bisoprolol（ 1.25 mg.bid.po）on the basis of conventional treatment. Obser- vation group （36 males and 16 females, aged from 62 to 88 years old） was treated with wenxinkeli （9 g. tid. po）based on former group. If efficacy of two group was poor, the dose of bisoprolol was added to 5 mg （qd. po）. The two groups were observed for 4 weeks. The frequence and duration time of atrial fibrillation and efficacy of post- treatment were observed. Results Frequence and duration time of atrial fibrillation were significantly reduced in two group. The difference between pre and post-treatment was significantly statistically significant （P〈0.01）, and the difference of observation group more clearly than control group. Differences of them were statistically significant （P〈0.05）. Clinical total effective rate was higher than the observation group. Difference was statistically significant （P〈0.05）. Conclusion The treatment of wenxinkeli for patients who have paroxysmal atrial fibrillation in senile patients is effective, and the combination of bisoprolol treatment is more effective than bisoprolol alone.