玻璃体内注射T—PA治疗实验性新鲜玻璃体积血

制作新鲜兔眼玻璃体积血模型，将t－PA、尿激酶（UK）及注射用水分别注入玻璃体内，观察眼底、测定玻璃体出血指数、测定玻璃体液纤维蛋白（原）降解产物（FDP）含量、进行鱼精蛋白副凝固（3P）试验，结果：t－PA可促进玻璃体积血吸收，作用快速，且优于UK，同对照组、UK组比较统计学上有非常显著差异；未发现毒副作用。

Intravitreal Tissue Plasminogen Activator Treatment of Experimental Vitreous Hemorrhage

T-PA is a tissue-type plasminogen activator which can produce highly selective lysis of fibrinclots andpromote rapid resolution of intravitreal fibrinclots. We made fresh models of vitreous hemorrhage in rabbits.The efficacy of t-PA in promoting the short-term clearance of vitreous hemorrhage was investigated withurokinase(UK) by ophthalmoscopy, vitreous hemorrhage index, vitreous concentration of fibrin (ogen) degration product (FDP) and 3P test. The t-PA. UK group showed a statistically significant difference as compared with control group,respectively. Moreover, t-PA group showed a statistically significant difference ascompared with UK. The results suggest that t-PA is effective on treatment of vitreous hemorrhage and hasan advantage over UK in efficacy. No evidence of toxicity was observed in t-PA group.