Infections and neutrophils in the pathogenesis of bronchiolitis obliterans syndrome in children after allogeneic stem cell transplantation |
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| Authors: | Adam Gassas Joerg Krueger Irina Zaidman Tal Schechter Hayley Craig‐Barnes Muhammad Ali Nades Palaniyar |
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| Affiliation: | 1. Division of Haematology/Oncology/BMT, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada;2. Division of Hematology/Oncology/BMT, Rambam Medical Center, Haifa, Israel;3. Programs of Physiology & Experimental Medicine, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada;4. Department of Laboratory Medicine and Pathobiology, and Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada |
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| Abstract: | ![]()
It is plausible that infections post‐hematopoietic SCT play a role in the pathogenesis of BOS. A prospective study for children with history, questionnaire, examination, PFTs, and blood counts at one, three, six, nine, 12, 18, and 24 months post‐SCT was conducted. Between September 2009 and September 2011 (n = 39), six developed BOS at 200 days (range 94–282), three patients had probable clinical respiratory infection, and all six had higher neutrophil count compared to non‐BOS patients (4.7 vs. 2.4 at three months and 6.3 vs. 2.9 at six months ×109/L, p = 0.03). Contribution of clinical and subclinical infection needs to be considered in the pathogenesis of BOS. |
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| Keywords: | bronchiolitis obliterans syndrome allogeneic SCT children infection neutrophils |
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