| T-bet、GATA-3在Th1、Th2细胞分化中的作用及意义 |
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| 引用本文： | 李峻,周永明,胡明辉. T-bet、GATA-3在Th1、Th2细胞分化中的作用及意义[J]. 国际免疫学杂志, 2009, 32(2): 126-131. DOI: 10.3760/cma.j.issn.1673-4394.2009.02.012 |
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| 作者姓名： | 李峻 周永明 胡明辉 |
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| 作者单位： | 上海中医药大学附属岳阳中西医结合医院血液科,200437;上海中医药大学附属岳阳中西医结合医院血液科,200437;上海中医药大学附属岳阳中西医结合医院血液科,200437 |
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| 基金项目： | 上海市教育委员会资助项目,上海市卫生局科研基金 |
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| 摘 要： | Th1、Th2细胞分化及其相互之间的平衡在免疫应答的调节中起重要作用,Th1／Th2细胞分化受多种因素影响,其中,转录因子T-bet、GATA-3对其具有重要的调节作用。多种疾病的发生、发展和预后均涉及Th1／Th2分化失衡。T-bet和GATA-3对Th1／Th2分化的调控作用、在疾病中的可能作用机制及其研究进展,有助于揭示多种疾病的发病机制,为治疗疾病提供帮助。
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| 关 键 词： | 转录因子 T-bet GATA-3 Th1/Th2分化 表观遗传学 |
The effects of T-bet /GATA-3 on the differentiation of Th1/Th2 cell and their clinical significances |
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| LI Jun,ZHOU Yong-ming,HU Ming-hui. The effects of T-bet /GATA-3 on the differentiation of Th1/Th2 cell and their clinical significances[J]. International Journal of Immunology, 2009, 32(2): 126-131. DOI: 10.3760/cma.j.issn.1673-4394.2009.02.012 |
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| Authors: | LI Jun ZHOU Yong-ming HU Ming-hui |
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| Affiliation: | LI Jun, HU Ming-hui, ZHOU Yong-ming (Department of Hematology, Yueyang Hospital of Integrated Tradi- tional and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China) |
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| Abstract: | The differentiation of Th1 ,Th2 cell and the balance between them play important roles in the regula-tion of immune responses. The differentiation ofThl ,Th2 cell is affected by several factors, in which transcrip-tion factors T-bet and GATA-3 are particularly important. Disequihbrium of Thl and Th2 differentiation is in-volved in pathogenesis, development and prognosis of many diseases. This article reviews the effects of T-bet/GATA-3 in the regulation of Th1/Th2 differentiation, their significance in the pathogenesis of diseases, and the study progress of these areas. This will help reveal pathogenesis of many diseases and provide new therapeutical approaches in clinical practices. |
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| Keywords: | T-bet GATA-3 |
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