| 曼陀罗种子化学成分研究 |
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| 引用本文： | 李建文,林彬彬,王国凯,高洪杰,秦民坚. 曼陀罗种子化学成分研究[J]. 中国中药杂志, 2012, 37(3): 319-322 |
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| 作者姓名： | 李建文 林彬彬 王国凯 高洪杰 秦民坚 |
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| 作者单位： | 1. 中国药科大学中药资源学教研室,江苏南京 211198;中国药科大学教育部现代中药研究重点实验室,江苏南京 210009
2. 中国药科大学教育部现代中药研究重点实验室,江苏南京,210009 |
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| 摘 要： | 目的:采用硅胶柱色谱、凝胶柱色谱Sephadex LH-20和MCI等各种柱色谱进行分离纯化,通过化合物的理化常数和波谱数据鉴定其结构。方法:采用硅胶柱色谱、凝胶柱色谱Sephadex LH-20和MCI等各种柱色谱进行分离纯化,通过化合物的理化常数和波谱数据鉴定其结构。结果:从曼陀罗种子的95%乙醇提取物中分离并鉴定了12个化合物,分别为N-trans-feruloyl tryptamine(1),hyoscyamilactol(2),东莨菪内酯(3),umckalin(4),曼陀罗萜醇酮(5),曼陀罗萜二醇(6),N-反式阿魏酰基酪胺(7),cleomiscosin A(8),秦皮素(9),东莨菪碱(10)1-acetyl-7-hydroxy-β-carboline(11),7-hydroxy-β-carboline1-propionic acid(12).结论:化合物2,7,9,12均为首次从曼陀罗属植物中分得;化合物1,4,8,11均为首次从茄科植物中分到。研究茄科Solanaceae植物曼陀罗Datura stramonium种子的化学成分。
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| 关 键 词： | 曼陀罗属 曼陀罗 种子 化学成分 |
| 收稿时间： | 2011-07-02 |
Chemical constituents of Datura stramonium seeds |
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| LI Jianwen,LIN Binbin,WANG Guokai,GAO Hongjie and QIN Minjian. Chemical constituents of Datura stramonium seeds[J]. China Journal of Chinese Materia Medica, 2012, 37(3): 319-322 |
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| Authors: | LI Jianwen LIN Binbin WANG Guokai GAO Hongjie QIN Minjian |
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| Affiliation: | Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 211198, China;Key Laboratory of Modern Traditional Chinese Medicines, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China;Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 211198, China;Key Laboratory of Modern Traditional Chinese Medicines, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China;Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 211198, China;Key Laboratory of Modern Traditional Chinese Medicines, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China;Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 211198, China;Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing 211198, China;Key Laboratory of Modern Traditional Chinese Medicines, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | Objective: To study chemical constituents in the seeds of Datura Stramonium(Solanaceae family).Method: Compounds were isolated and purified by silica gel,MCI and Sephadex LH-20 column chromatography,and their structures were determined based on physicochemical constants and spectroscopic analysis including NMR and MS.Result: Twelve compounds were isolated and identified from Datura stramonium,they were N-trans-feruloyl tryptamine(1),hyoscyamilactol(2),scopoletin(3),umckalin(4),daturaolone(5),daturadiol(6),N-trans-ferulicacyl-tyramine(7),cleomiscosin A(8),fraxetin(9),scopolamine(10),1-Acetyl-7-hydrox-β-carbol-ine(11),7-hydroxy-β-carboline1-propionic acid(12).Conclusion: Compound 2,7,9 and 12 were obtained from Datura genus for the first time,whereas compound 1,4,8 and 11 were obtained from the Solanaceae family for the first time. |
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| Keywords: | Datura Datura stramonium seed chemical constituent |
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