| 银杏叶制剂中银杏酚酸研究进展 |
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| 引用本文： | 刘平平,潘苏华.银杏叶制剂中银杏酚酸研究进展[J].中国中药杂志,2012,37(3):274-277. |
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| 作者姓名： | 刘平平 潘苏华 |
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| 作者单位： | 南京中医药大学江苏省中药药效与安全评价重点实验室,江苏南京,210046 |
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| 基金项目： | 江苏省中医局基金项目(H-024) |
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| 摘 要： | 银杏叶具有很高药用价值,银杏叶提取物(GBE)中的黄酮醇苷与萜类内酯分别具有抗氧化、抗血小板聚集及改善记忆、增强免疫等药理作用。但银杏叶中含有的银杏酸(GA)有强致敏性及细胞毒性,即使在制剂中微量残留也能引起严重的不良反应。为减少银杏类制剂用药安全隐患,该研究从GA的化学结构,不良反应与毒性及发生机制,GA脱除与减毒等进行综述,期望为提高银杏叶制剂的安全性研究提供新思路。
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| 关 键 词： | 银杏酚酸 不良反应 机制 配伍减毒 |
| 收稿时间： | 4/8/2011 12:00:00 AM |
Advance in study of ginkgolic acid contained in Ginkgo biloba preparations |
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| LIU Pingping and PAN Suhua.Advance in study of ginkgolic acid contained in Ginkgo biloba preparations[J].China Journal of Chinese Materia Medica,2012,37(3):274-277. |
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| Authors: | LIU Pingping and PAN Suhua |
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| Institution: | Nanjing University of Chinese Medicine, Nanjing 210046, China;Nanjing University of Chinese Medicine, Nanjing 210046, China |
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| Abstract: | Ginkgo biloba has a very high medicinal value. The flavonol glycosides and terpene lactones contained in G. biloba extract (GBE) have such pharmacological effects as antioxidant, anti-platelet aggregation and memory improvement, enhancement of immune function. However, the ginkgolic acid (GA) contained in GBE is proved to be highly allergenic and cytotoxic, even minimal residual could also cause severe adverse effects. To minimize the potential safety hazards of ginkgo leaf preparations, this study focuses on GA's chemical structure, adverse effects, toxicity and genesis mechanism, desorption and attenuation in the hope of providing a new thought for studies on safety of Ginkgo biloba preparations. |
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| Keywords: | ginkgolic acid adverse effects mechanism attenuated compatibility |
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