密闭性敷料支架的制备及其性能

背景：近年来创伤敷料的研究发展较快，但很少有中药联合高分子材料制备的复合密闭敷料，且现有的创伤敷料作用较局限，不能适用于任何创伤伤口。 目的：制备适用于中药载入的密闭敷料支架，并测定其性能。 方法：将壳聚糖、明胶、聚乙烯醇，壳聚糖、明胶、聚乙烯醇和海藻酸钠分别在一定条件下共混，预冻，冷冻干燥得到支架，考察两支架的吸水性、含水量、相对保湿性、透气性、孔隙率、支架的外形。 结果与结论：壳聚糖、明胶、聚乙烯醇所制成支架的吸水性、含水量、相对保湿性、孔隙率优于壳聚糖、明胶、聚乙烯醇和海藻酸钠所制成的支架，两组比较差异有显著性意义(P < 0.05)。说明壳聚糖、明胶、聚乙烯醇适宜作为密闭敷料支架材料。 关键词：敷料支架；壳聚糖；明胶；海藻酸钠；聚乙烯醇 doi:10.3969/j.issn.1673-8225.2010.29.002

Preparation and property of closed dressing intelligent scaffolds

BACKGROUND: In recent years, the wound dressing research has developed quickly, but few reports the closed dressings prepared by traditional Chinese medicine combined with polymer composite, the efficacy of existing wound dressings is limited and not suitable for all wounds. OBJECTIVE: To prepare closed dressing scaffolds loading traditional Chinese medicine, and to determine their properties. METHODS: Firstly the chitosan, gelatin and polyvinyl alcohol were mixed, while the above materials were additionally mixed with sodium alginate. The scaffolds were prepared by mixing, precooling and freeze drying. The properties of the enclosed dressing scaffolds was evaluated by water absorption, moisture content, relative moisture retention, permeability, porosity, and scaffold appearance. RESULTS AND CONCLUSION: Water absorption, moisture content, relative moisture retention and porosity of the mixture of chitosan, gelatin and polyvinyl alcohol were significantly better than those of the mixture containing chitosan, gelatin, polyvinyl alcohol and sodium alginate (P < 0.05). Chitosan, gelatin and polyvinyl alcohol are suitable to be used as closed dressing intelligent scaffolds.