小细胞肺癌41例临床病理分析

目的：探讨小细胞肺癌的临床病理特征，免疫组化特点及组织起源。方法：回顾分析41例小细胞肺癌的临床病理资料和免疫组化标忘物的表达情况。结果：小细胞肺癌男女之比为2．7：1，平均年龄58．6岁，63．4％有区域淋巴结转移。免疫标记CD56、NSE、CgA、Syn、CKpan、LCA的阳性率分别为90．2％、85．4％、68．3％、73．2％、92．7％、0。结论：小儿细胞肺癌具有恶性程度高、进展快、容易转移以及对神经细胞黏附分子、神经内分泌源性抗体和上皮源性抗体标记阳性等特点，其组织起源倾向于支气管黏膜干细胞。

Clinicopathologic analysis of 41 cases of small cell lung carcinoma

Objective：To investigate the elinicopathologic characteristics, immunohistochemical features, and histogenesis of the small cell lung carcinoma. Methods：The clinical data, pathological findings, and results of immunohistochemical staining were retrospectively studied in 41 cases of small cell lung carcinoma. Results：The ratio of man to woman was 2.7 to 1;The average age was 58.6 years old; 63.4% of eases had lymph node metastasis.The positive rate of immunohistochemical staining of CD56, NSE, CgA, Syn, CKpan and LCA respectively was 90.2%,85.4%,68.3%,73.2%,92.7%,0. Conclusion： Small cell lung carcinoma is a high malignant tumor with rapid progression and early metastasis characteristics.The results suggest this tumor may origin from the bronchi mucosa stem cells.