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Shared Genetics of Multiple System Atrophy and Inflammatory Bowel Disease |
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| Authors: | Alexey A. Shadrin PhD Sören Mucha PhD David Ellinghaus PhD Mary B. Makarious BSc Cornelis Blauwendraat PhD Ashwin A.K. Sreelatha MSc Antonio Heras-Garvin PhD Jinhui Ding PhD Monia Hammer PhD Alexandra Foubert-Samier MD Wassilios G. Meissner MD Olivier Rascol PhD Anne Pavy-Le Traon MD Oleksandr Frei PhD Kevin S. O'Connell PhD Shahram Bahrami PhD Stefan Schreiber MD Wolfgang Lieb MD Martina Müller-Nurasyid PhD Ulf Schminke MD Georg Homuth PhD Carsten O. Schmidt PhD Markus M. Nöthen MD Per Hoffmann PhD Christian Gieger PhD Gregor Wenning MD for the European Multiple System Atrophy Study Group J. Raphael Gibbs PhD Andre Franke PhD John Hardy PhD Nadia Stefanova PhD Thomas Gasser MD Andrew Singleton PhD Henry Houlden MD Sonja W. Scholz MD Ole A. Andreassen PhD Manu Sharma PhD |
| Affiliation: | 1. NORMENT, Institute of Clinical Medicine, University of Oslo and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway;2. Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany These authors contributed equally.;3. Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and, Stroke, National Institutes of Health, Bethesda, Maryland, USA;4. Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA;5. Centre for Genetic Epidemiology, Institute for Clinical Epidemiology and Applied Biometry, University of Tübingen, Tübingen, Germany;6. Department of Neurology, Medical University of Innsbruck, Innsbruck, Austria;7. Service de Neurologie, CRMR Atrophie Multisystématisée, CHU Bordeaux, Bordeaux, France Inserm, UMR1219, Bordeaux Population Health Research Center, Bordeaux University, ISPED, Bordeaux, France;8. Service de Neurologie, CRMR Atrophie Multisystématisée, CHU Bordeaux, Bordeaux, France;9. Centre de Reference Maladie Rare Atrophie MultiSystématisée, Centre d'Investigation, Clinique CIC 1436, Services de Pharmacologie Clinique et Neurosciences, NeuroToul COEN Center, Toulouse, France Centre Hospitalo-Universitaire de Toulouse, 3, INSERM, Toulouse, France;10. Neurology Department, French Reference Centre for MSA, University Hospital of Toulouse and INSERM U 1048, Institute of Cardiovascular and Metabolic Diseases, Toulouse, France;11. Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany First Medical Department, University Hospital Schleswig-Holstein, Kiel, Germany;12. Institute of Epidemiology and Biobank PopGen, Christian-Albrechts-University of Kiel, Kiel, Germany;13. Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany Chair of Genetic Epidemiology, IBE, Faculty of Medicine, Ludwig-Maximilians-University (LMU) Munich, Munich, Germany Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University (LMU) Munich, Munich, Germany;14. Department of Neurology, University Medicine Greifswald, Greifswald, Germany;15. Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany;16. Institute for Community Medicine, Study of Health in Pomerania/KEF, University Medicine Greifswald, Greifswald, Germany;17. Institute of Human Genetics, University of Bonn, Bonn, Germany;18. Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany;19. Full list of the European Multiple System Atrophy Study Group members is available in the Supplementary Table.;20. Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany;21. Rita Lila Weston Institute, University College London, London, UK;22. German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany Department of Neurodegenerative Diseases, Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany |
| Abstract: | |
| Keywords: | multiple system atrophy inflammatory bowel disease genetic overlap conjunctional false discovery rate |