Long-term comorbidity of diabetes mellitus is a risk factor for perineal wound complications after an abdominoperineal resection |
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Authors: | Kenji Matsuda Tsukasa Hotta Katsunari Takifuji Shozo Yokoyama Takashi Higashiguchi Toshiji Tominaga Yoshimasa Oku Toru Nasu Koichi Tamura Hiroki Yamaue |
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Affiliation: | (1) Second Department of Surgery, School of Medicine, Wakayama Medical University, 811-1, Kimiidera, Wakayama 641-8510, Japan |
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Abstract: | Background This report is an attempt to clarify the effect of diabetes mellitus on perineal wound complications including infectious entities and delayed wound healing after abdominoperineal resection and also tried to show the risk factors for perineal wound complications. Material and methods The data of 80 patients who underwent an abdominoperineal resection were reviewed from April 1996 to March 2006. Results The rate of perineal wound complications is higher in diabetics (67%) than in nondiabetics (18%, p = 0.005). In a multivariate analysis, diabetes mellitus and operation time (≥420 min) were the risk factors for perineal wound complications (p = 0.040, p = 0.027, respectively). Infectious perineal wound complication was associated with diabetes mellitus (p < 0.001) but not with the operation time (p = 0.097). Furthermore, a longer comorbid duration of diabetes (≥10 years) was a significant predictor for perineal wound complications (p = 0.008). Conclusion This study demonstrated diabetes mellitus to be independently associated with perineal wound complications, and when the patients have diabetes mellitus, especially with a longer comorbid duration and longer operation time, the clinical path should be changed to reduce perineal wound complications. |
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Keywords: | Diabetes mellitus Perineal wound complications Abdominoperineal resection |
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