| 胰岛素、胰岛素样生长因子Ⅰ及其受体在PCOS患者子宫内膜的表达 |
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| 引用本文： | 印立鸿,乔杰,李蓉,高冬霞,张小为,李美芝.胰岛素、胰岛素样生长因子Ⅰ及其受体在PCOS患者子宫内膜的表达[J].中国优生与遗传杂志,2008,16(10). |
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| 作者姓名： | 印立鸿 乔杰 李蓉 高冬霞 张小为 李美芝 |
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| 作者单位： | 北京航天中心医院妇产科 北京大学第三医院生殖医学中心 北京大学第三医院病理科 |
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| 摘 要： | 目的探讨胰岛素及其受体、胰岛素样生长因子I及其受体在多囊卵巢综合征患者子宫内膜的表达特点。方法利用免疫组化实验技术分析INS、INS-R、IGF-I和IGF-IR在多囊卵巢综合征和非多囊卵巢综合征不孕症患者子宫内膜中的表达情况,对结果进行图像分析,并利用SPSS10.0软件进行统计学分析,比较各组间的差异。结果1.多囊卵巢综合征患者子宫内膜IGF-I和INS-R表达水平明显高于对照组,差异有显著性(P<0.01)。其中多囊卵巢综合征中子宫内膜增生症患者的IGF-I和INS-R表达水平高于多囊卵巢综合征组增殖期患者,差异有显著性(P<0.05)。2.IGF-IR和INS在多囊卵巢综合征患者与对照组子宫内膜的表达水平无明显差异(P>0.05)。结论多囊卵巢综合征患者子宫内膜异常增生可能与局部IGF-I和INS-R表达异常有关。
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| 关 键 词： | 多囊卵巢综合征 胰岛素 胰岛素受体 胰岛素样生长因子 胰岛素样生长因子受体 |
Expression of insulin, Insulin - like growth factor - I and their receptor in endometrium in patients with PCOS |
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| YIN Li-hong,QIAO Jie,LI Rong,GAO Dong-xia,ZHANG Xiao-wei,LI Mei-zhi.Expression of insulin, Insulin - like growth factor - I and their receptor in endometrium in patients with PCOS[J].Chinese Journal of Birth Health & Heredity,2008,16(10). |
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| Authors: | YIN Li-hong QIAO Jie LI Rong GAO Dong-xia ZHANG Xiao-wei LI Mei-zhi |
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| Institution: | YIN Li-hong; QIAO Jie; LI Rong; GAO Dong-xia; ZHANG Xiao-wei; LI Mei-zhi.(Department of Obstetrics and Gynecology; Peking University Third Hospital; Beijing 100083 China); |
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| Abstract: | Objective:To study the expression of insulin and its receptor,Insulin-like growth factor-I and its receptor in endometrium of patients with PCOS.Methods:Detecting the expression of the level of insulin and its receptor,Insulin-like growth factor-I and its receptor in endometrium in patients with PCOS and non PCOS by using immunohistochemical method.Results:The expression intensity of Insulin-like growth factor-I and insulin receptor in endometrium of patients with PCOS were significantly higher than those o... |
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| Keywords: | Polycystic ovary syndrome Insulin Insulin receptor Insulin-like growth factor Insulin-like growth factor I receptor |
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