肝癌患者中nm23-H_1表达与转移 复发的关系

目的探讨肿瘤转移抑制因子nm23-H1基因在肝癌组织中的表达以及与转移、复发、预后的关系。方法应用免疫组织化学SP法对36例肝癌组织、30例正常组织进行nm23-H1基因蛋白检测,并追踪随访1年。结果肝癌低分化组中nm23-H1基因蛋白表达阳性率为26%,明显低于高、中分化组及正常组织(P<0.05),nm23-H1基因蛋白表达在肝内转移组明显低于无肝内转移组,两组间差异有统计学意义(P<0.01);nm23-H1基因蛋白表达在术后复发组明显低于术后无复发组。结论nm23-H1基因蛋白与肝癌的转移、复发及预后密切相关。

Relations between expression of nm23-H_1 genic protein and clinical metastasis and relapse in patients with liver cancer

Objective The purpose of this study was to investigate the association between the expression of genic protein nm23-H1 and clinical metastasis and relapse in patients with primary liver cancer.Methods nm23-H1 genic protein was detected by immunohistochemical method of strept-avidin-peroxidase(SP)in 36 primary liver cancer,and tracing for 1 year.Results The positive rate of nm23-H1 expression in the low differentiated primary liver cancer tissues(26%)was significantly lower than that in the high and middle differentiated cancer tissues,and the normal tissues(P<0.05),the positive rate of nm23-H1 expression in liver cancer without lymph node metastasis was significantly lower than that in liver cancer with lymph node metastasis(P<0.01).Conclusion nm23-H1 expression is closely related to the metastasis and relapse of liver cancer.