| 丹参对大鼠急性脑缺血再灌注后脑水肿的作用观察 |
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| 引用本文： | 曾祥发,任丁,陆晖,谢林,陈耀宇,谢泽明.丹参对大鼠急性脑缺血再灌注后脑水肿的作用观察[J].卒中与神经疾病,1994(2). |
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| 作者姓名： | 曾祥发 任丁 陆晖 谢林 陈耀宇 谢泽明 |
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| 作者单位： | 广西中医学院第二附属医院 |
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| 摘 要： | 本实验通过建立大鼠急性不完全性脑缺血再灌注后脑损害模型，观察丹参对其损害的作用。丹参实验组脑组织含水量为７８．０５％±０．９１％，脑组织的钠含量为４５２．１１±２３．１ｍｍｏｌ／ｋｇ干重，对照组分别为８０．２２％±１．０％和４７６．２±３７．２１ｍｍｏｌ／ｋｇ干重（Ｐ＜０．０５）。结果表明显示丹参具有减轻脑水肿，降低脑组织的钠含量的作用。通过病理检查显示丹参具有维护血脑屏障完整性和减轻神经细胞损害的作用。
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| 关 键 词： | 丹参 脑缺血 再灌注 脑水肿 |
An Observation on the Effect of SM in Brain Edema of Rats Following Acute Cerebral Ischemia and Postischemia Reperfusion |
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| Zhen Xiangfa,Ren Ding,Lu Hui,et al.An Observation on the Effect of SM in Brain Edema of Rats Following Acute Cerebral Ischemia and Postischemia Reperfusion[J].Stroke and Nervous Diseases,1994(2). |
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| Authors: | Zhen Xiangfa Ren Ding Lu Hui |
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| Abstract: | With the rat model of acute,partial cerebral ischemia and reperfusion,we conducted the experiment to study the effects of Salvia Miltirrhizae(SM).The results showed that brain water and sodium contents were 78.05% 0.91% and 452.11 23.11 mmol/kg(dry weight)respectiveky in SM group,and 80.22% 1.01%,476.21 37.21 mmol/kg(dry weight) in contral group.By comparison,the differences between the two groups were significent.It indicated that SM might decrease brain edema and reduce the sodium content of brain. Pathologic results suggested SM should have protecting effects on the integrity of blood-brain barrier and the effects on relief of injuries of neurocytes as well. |
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| Keywords: | Salvia miltirrhizac Cerebral ischemia Reparfusion Brain edema |
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