Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells |
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| Authors: | Jakubíková Jana Sedlák Ján Mithen Richard Bao Yongping |
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| Affiliation: | Nutrition Division, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK. |
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| Abstract: | ![]()
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| Keywords: | Akt, protein kinase B ERKs, extracellular signal-regulated kinases ITCs, isothiocyanates JNK, c-Jun N-terminal kinase MAPKs, mitogen-activated protein kinases MRP2, multidrug resistance-associated protein 2 NF-κB, nuclear factor-kappa B NQO1, NADP(H):quinine oxidoreductase Nrf2, nuclear factor E2-related factor 2 PBS, phosphate-buffered saline PI, propidium iodide PI3K, phosphoinositide 3-kinase UGTs, UDP-glucuronosyl transferases TBS, Tris-buffered saline |
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