升陷汤辅助治疗对慢性阻塞性肺疾病急性加重期患者氧化应激及炎症指标的影响

目的:探讨升陷汤辅助治疗对慢性阻塞性肺疾病急性加重期患者氧化应激及炎症指标的影响。方法:选取2018年1月—2019年11月天津市宁河区中医医院收治的80例急性加重期慢性阻塞性肺疾病患者为研究对象,随机分为观察组和对照组,每组各40例。对照组予以吸氧、化痰、平喘等常规西医治疗,观察组在对照组基础上增用升陷汤,疗程均为14d。比较两组临床疗效、中医证候积分、氧化应激指标[血清丙二醛(MDA)、超氧化物歧化酶(SOD)]、炎症指标[C-反应蛋白(CRP)、降钙素原(PCT)]。结果:观察组治疗后中医证候积分、MDA水平明显低于对照组,SOD水平明显高于对照组(P<0.05)。观察组治疗后CRP、PCT水平明显低于对照组(P<0.05)。观察组临床总有效率(85.00%)明显高于对照组(70.00%)(P<0.05)。结论:对慢性阻塞性肺疾病患者采用升陷汤进行辅助治疗,疗效良好,可明显改善临床症状、氧化应激指标水平,可减轻炎症反应。

Effect of Shengxian Decoction Adjuvant Treatment on Oxidative Stress and Inflammation Indexes in Patients with Chronic Obstructive Pulmonary Disease in Acute Exacerbation Stage

Objective:To investigate the effect of Shengxian Decoction on oxidative stress and inflammation indexes in patients with acute exacerbation of chronic obstructive pulmonary disease.Methods:From January 2018 to November 2019,80 patients with acute exacerbation of chronic obstructive pulmonary disease admitted to the Hospital of Traditional Chinese Medicine in Tianjin Ninghe District were selected as the research objects,and they were randomly divided into observation group and control group,with 40 cases in each group.The control group was given conventional western medicine treatments such as oxygen inhalation,phlegm resolving,and asthma.The observation group was given Shengxian Decoction on the basis of the control group,and the course of treatment was 14 days.The clinical efficacy,TCM syndrome score,oxidative stress indicators[serum malondialdehyde (MDA),superoxide dismutase (SOD)],inflammation indicators[C-reactive protein (CRP),procalcitonin (PCT)].Results:After treatment,the TCM syndrome score and MDA levels of the observation group were significantly lower than those of the control group,and the SOD level was significantly higher than that of the control group (P<0.05).CRP and PCT levels in the observation group were significantly lower than those in the control group after treatment (P<0.05).The total clinical effective rate of the observation group (85.00%) was significantly higher than that of the control group (70.00%) (P<0.05).Conclusion:Adjuvant treatment with Shengxian Decoction for patients with chronic obstructive pulmonary disease has good curative effect,can significantly improve clinical symptoms,oxidative stress index levels,and reduce inflammation.