| 肾上腺素能受体在脾脏红细胞储存与释放的动力机制中的作用 |
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| 引用本文： | 孙树津 龙天渝. 肾上腺素能受体在脾脏红细胞储存与释放的动力机制中的作用[J]. 中国血液流变学杂志, 1998, 8(1): 8-12 |
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| 作者姓名： | 孙树津 龙天渝 |
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| 作者单位： | [1]国家教委生物力学及生物流变学开放实验室 [2]重庆大学 |
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| 摘 要： | 通过对狗的脾脏进行α受体阻断情况下的低浓度肾上腺素溶液在体灌注实验，探讨了脾脏储存与释放血细胞的微循环动力机制。实验结果支持Ｇｒｏｏｍ提出的脾索内肌质纤维友交感神经控制下和血液调节机制，并认为脾索及静脉窦壁的过滤作用是调节脾内红细胞浓度的主要因素，但并非如Ｍａｃｋｅｎｚｉｅ和ＪΦｒｇｅｎ等人认为的红细胞被动地滞留于脾索中，而是存在交感神经及血液中儿荷胺调控下的主动机制。
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| 关 键 词： | 脾脏 红细胞 肾上腺素能受体 血球比积 |
THE EFFECT OF ADRENERGIC RECEPTORS ON THE DYNAMIC MECHANISM OF SPLENIC RESERVE AND DISCHARGE RED BLOOD CELLS |
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| Sun Shujin,Long Tianyu,Yu Weigun,Cai Shaoxi. THE EFFECT OF ADRENERGIC RECEPTORS ON THE DYNAMIC MECHANISM OF SPLENIC RESERVE AND DISCHARGE RED BLOOD CELLS[J]. Chinese Journal of Hemorheology, 1998, 8(1): 8-12 |
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| Authors: | Sun Shujin Long Tianyu Yu Weigun Cai Shaoxi |
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| Abstract: | The splenic red blood cell reserve and discharge mechanism was studied by perfusing adrenaline solution of low concentration into splenic arteries after a-receptors in the spleen were blocked in anaesthetized dogs. The analysis to the experiments supports the splenic blood regulation mechanism involving active contraction of intra-reticulocytic skeletal filamets under the control of sympathetic nerve proposed by Groom. Red blood cells are not reserved passively by filtration of the red pulp as Mackenzie and Jorgen suggested, but by active dilation of reticulocytes or endotheliocytes of venous sinuses controlled sympathetic nerve and catechnolamine in blood. |
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| Keywords: | Spleen Red blood cell (RBC) Adrenergic receptor Haematocrit |
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