海冬花粉对下丘脑性肥胖大鼠的影响

目的 :探讨药食同源的中药制剂海冬花粉的减肥作用及机理。方法 :应用L 谷氨酸钠致下丘脑性肥胖的大鼠模型研究海冬花粉的药效及其机理。结果 :海冬花粉 (2.5 g·kg^-1)能降低肥胖动物的Lee′s指数 (身高体重指数 ) ,使脂肪细胞变小 ;对血清三碘甲腺原氨酸 (T³ )、甲状腺素 (⁴ )、胰岛素和醛固酮水平无明显影响 ;对摄入热量无影响 ;无腹泻现象。结论 :海冬花粉具减肥作用 ,其减肥不影响甲状腺功能和水盐代谢 ,不引起腹泻和不抑制食欲。其减肥机理与阻碍脂肪细胞的增大 ,减少脂肪蓄积有关。

Effect of Haidonghua Powder(HDHP) on Hypothalamic Obesity in Rats

Objective:To study the effect of HDHP including Laminaria japonica Aresch.and Benincasa hispida (Thunb.)Cogn.etc.on antiobesity in rats with hypothalamic obesity. Method:A rat model of hypothalamic obesity induced by MSG was used and the relative indexes was observed.Result:HDHP(2.5 g·kg^-1 )could significantly reduce the Lee's index as well as the size of fat cells.HDHP did not influence the serum levels of T₃ and T₄, insulin and aldosterone,did not inhibited appetite not led to diarrhea.Conclusion:HDHP has the effect of anti obesity,Without any influencing on the function of thyroid gland and metabolism of water and salt.The mechanism is related to the reduction of fat cell size and the accumulation of fat.