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Feasibility of azithromycin prophylaxis during a pertussis outbreak among healthcare workers in a university hospital in Paris. |
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| Authors: | Camila Giugliani Gwenaelle Vidal-Trecan Souleymane Traore Herve Blanchard Gabriela Spiridon Florence Rollot Odile Launay Myriam Gorodestski Jean-Luc Marande Christophe Vinsonneau Loic Guillevin Dominique Salmon-Ceron |
| Affiliation: | Service de Sante Publique, Groupe Hospitalier Cochin-St. Vincent de Paul, Paris, France. |
| Abstract: | The objective of the present study was to evaluate the feasibility of azithromycin prophylaxis with respect to tolerability and compliance during a pertussis outbreak among healthcare workers in a university hospital ward. Compliance with the prophylaxis regimen was 89%; compliance was 75% from intent-to-treat perspective. The rate of adverse events was 33%. Female sex was associated with reporting of adverse events. Nonstudents and healthcare workers who reported adverse events were less compliant with the prophylaxis regimen. |
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