热休克蛋白90在食管鳞癌中的表达及临床意义

食管鳞状细胞癌(Esophagus squamous cell carcinoma,ESCC)是我国食管癌的主要病理分型,它起病隐匿、转移速度快,且给予治疗时产生耐药的速度快,导致预后不理想。热休克蛋白90(Heat shock protein 90,HSP90)调控的众多下游蛋白参与细胞的增殖等过程,所以在恶性肿瘤的发生发展中常扮演重要角色。越来越多的研究证实HSP90在多种恶性肿瘤中高表达并可影响肿瘤耐药性。近年来,对HSP90在ESCC中相关作用的探索也收获了许多值得关注的成果,本文将对HSP90在ESCC中的表达及临床意义做一综述。

Expression and clinical significance of heat shock protein 90 in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma(ESCC)is the main pathological type of esophageal carcinoma in China.It is characterized by an insidious onset,rapid metastasis,and rapid drug resistance during treatment,resulting in an unsatisfactory prognosis.Many downstream proteins regulated by heat shock protein 90(HSP90)are involved in cell proliferation and other processes,so they often play an important role in the occurrence and development of malignant tumors.More and more studies have confirmed that HSP90 is highly expressed in a variety of malignant tumors and can affect tumor resistance.In recent years,the exploration relevant role of HSP90 in ESCC has also yielded many achievements worthy of attention.This article will review the expression and clinical significance of HSP90 in ESCC.