| Sirtuins在乳腺癌中作用机制的研究进展 |
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| 引用本文： | 李钰莹,张悦. Sirtuins在乳腺癌中作用机制的研究进展[J]. 实用肿瘤学杂志, 2021, 35(3): 277-281. DOI: 10.11904/j.issn.1002-3070.2021.03.016 |
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| 作者姓名： | 李钰莹 张悦 |
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| 作者单位： | 哈尔滨医科大学附属肿瘤医院(哈尔滨 150081) |
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| 基金项目： | 哈尔滨附属肿瘤医院海燕基金(编号:JJZD2020-10) |
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| 摘 要： | 乳腺癌是女性最常见的恶性肿瘤之一,导致其相关死亡的两大因素是复发转移及多药耐药(Multidrug resistance,MDR)。Sirtuins家族蛋白是一类NAD+依赖性去乙酰化酶,在多种生物学过程及疾病中发挥重要作用,与乳腺癌的发生发展及MDR有关。掌握Sirtuins在乳腺癌的作用机制至关重要,因此本文就Sirtuins家族在乳腺癌中的作用展开综述,讨论Sirtuins家族各亚型对乳腺癌发生发展及MDR的作用机制,并总结目前Sirtuins相关药物的研究进展。
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| 关 键 词： | 乳腺癌 SIRTs 多药耐药 |
| 收稿时间： | 2020-08-22 |
Research progress of Sirtuins in breast cancer |
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| LI Yuying,ZHANG Yue. Research progress of Sirtuins in breast cancer[J]. Journal of Practical Oncology, 2021, 35(3): 277-281. DOI: 10.11904/j.issn.1002-3070.2021.03.016 |
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| Authors: | LI Yuying ZHANG Yue |
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| Affiliation: | Harbin Medical University Cancer Hospital,Harbin 150081,China |
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| Abstract: | Breast cancer is one of the most common malignant tumors in women.The two major factors leading to its related deaths are recurrence,metastasis and multidrug resistance(MDR).Sirtuins family proteins are a class of NAD+-dependent deacetylases,which play an important role in various biological processes and diseases,and are related to the occurrence and development ofbreast cancer and MDR.It is very important to grasp the mechanism of Sirtuins in Breast cancer.Therefore,this article summarizes the role of Sirtuins in breast cancer,discusses the mechanism of each subtype of Sirtuins family on the occurrence and development of breast cancer and MDR,and summarizes the current research progress of Sirtuins related drugs. |
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| Keywords: | Breast cancer SIRTs Multidrug resistance |
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