Crohn's disease with pulmonary manifestations in children: 2 case reports and review of the literature |
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| Affiliation: | 1. Division of Pediatric Gastroenterology and Nutrition, Children''s of Alabama, Birmingham, AL, USA;2. Department of Pathology, Children''s of Alabama, Birmingham, AL, USA;3. Department of Pulmonology, Children''s of Alabama, Birmingham, AL, USA;4. Division of gastroenterology, Cleveland Clinic Foundation, Cleveland, OH, USA;1. ISPB faculté de pharmacie, université Claude-Bernard–Lyon 1, 69008 Lyon, France;2. Centre de biologie sud, hospices civils de Lyon, 69310 Pierre-Bénite, France;3. Service de nutrition clinique intensive, hospices civils de Lyon, 69310 Pierre-Bénite, France;4. The Medical School, University of Nottingham, Queen''s Medical Centre, Nottingham NG7 2UH, Royaume-Uni;1. Service d’hépatologie et transplantation hépatique pédiatriques, hôpital Bicêtre, centre de référence de maladies rares du foie de l’enfant, DHU Hepatinov, université Paris-Saclay, 78, rue du Général Leclerc, 94270 Le Kremlin-Bicêtre, France;2. Unité d’hépatologie pédiatrique, hôpital Necker, université Paris VI, 75012 Paris, France;3. Groupe francophone d’hépatologie, gastroentérologie et nutrition pédiatriques, 330, avenue de Grande-Bretagne, TSA 70034, 31000 Toulouse, France;4. Inserm UMR-S 1174, university Paris-Saclay, 91405 Orsay, France |
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| Abstract: | Crohn's disease (CD) is a chronic granulomatous disease of unknown etiology that affects primarily the gastrointestinal system but can be associated with extraintestinal manifestations. Latent pulmonary involvement in children with CD has been described, but symptomatic pulmonary disease has rarely been reported in children. In this review, we report two pediatric cases, one with pleural effusion at the time of CD diagnosis and the other with bilateral cavitary lesions in a previously diagnosed CD patient. We review the current literature and summarize the diagnosis and management of pulmonary involvement in CD. Awareness of these pulmonary complications of CD in children may lead to more prompt diagnosis, guide appropriate therapy, and decrease morbidity. |
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