化疗对肺癌患者细胞免疫功能的影响

目的探讨肺癌患者细胞免疫功能及化疗药物对其影响。方法选择46例肺癌患者,于化疗前、化疗后一周、二周,采用碱性磷酸酶抗碱性磷酸酶(APAAP)法测定外周血T淋巴细胞亚群及NK(自然杀伤)细胞,并与20例健康人作对照。结果肺癌组、CD

Effect of chemotherapy oncell immunofunction in patients o f lung cancer

Objective　To investigate the effect of chemothera peutic drugs on cellular immunity in patients with lung cancer.Methods　46 patients of lung cancer were enrolled in the study. Alkaline phosphat a se anti-alkaline phosphatase(APAAP) assay was used to measure the T lymphocyte s ubsets and natural killer cell in peripheral blood before chemotherapy,a week af ter chemotherapy and two weeks after chemotherapy,and comparison to 20 nomal con trols was made.Results　We found that:(1)The level of CD+3、 CD+4、CD+4/CD+8,NK cell in pafients of lung cancer were significantl y decreased compared with the control(P<0.001).(2)The level of CD+3、CD+ 4、CD+8.NK cell after chemotherapy was all decreased compared with that befo re chemotherapy respectively(P<0.001),however the level of CD+4/CD+8 aft er chemtherapy was significantly increased compared with that before chemotherap y (P<0.001). Conclusions　The cell immunity is inhibited in patients of lung cancer moreover is impared considerably by chemotherapy,however at the same tim e chemotherapy can regulate the immunefunction as immunomodulator.