Pathologic,radiologic and PET scan response of gastrointestinal stromal tumors after neoadjuvant treatment with imatinib mesylate |
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| Affiliation: | 1. Department of Pediatrics, Queen Sirikit National Institute of Child Health, Bangkok 10400, Thailand;2. College of Medicine, Rangsit University, Bangkok 10400, Thailand;3. Center of Excellence for Medical Genomics, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand;4. Excellence Center for Medical Genetics, King Chulalongkorn Memorial Hospital, the Thai Red Cross Society, Bangkok 10330, Thailand;1. Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA;2. Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA;3. Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, NE, USA;4. Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA;5. Department of Otolaryngology-Head & Neck Surgery, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA;6. Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA;7. Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE, USA;1. Department of Histopathology and Morbid Anatomy, Trinity Translational Medicine Institute, Trinity College Dublin, Ireland;2. Department of Urology, Faculty of Medicine and Health, Örebro University, Orebro, Sweden;3. School of Medicine, Trinity Translational Medicine Institute, Trinity College Dublin, Ireland;4. Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Switzerland;5. Thoracic Oncology Research Group, Trinity Translational Medicine Institute, Trinity College Dublin, Ireland;6. UCD School of Medicine, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland;7. Department of Histopathology, St James''s Hospital, Dublin, Ireland |
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| Abstract: | ![]()
AimThe aim of this study is to review the radiologic, PET scan and pathologic response and the outcome of patients with advanced GIST treated with neoadjuvant IM followed by surgical resection.Materials and methodsWe report a case and review 36 patients reported in MEDLINE with advanced GIST treated with neoadjuvant IM followed by surgical resection.ResultsThirty-seven patients with a median age of 56 years (range, 32–76 years) at presentation were treated with neoadjuvant IM. Radiologic response accurately predicted pathological response in 31/36 patients, whereas PET scan was accurate in predicting treatment response in only 6/23 patients.ConclusionThis study demonstrates that the pathologic response of GIST to IM is usually incomplete and does not correlate with the complete response seen on PET scan. This finding suggests that surgical resection will continue to play a vital role in the treatment of patients with advanced disease responding to IM treatment. |
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