| 硝酸益康唑微胶囊的制备及性能研究 |
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| 引用本文： | 范润珍,万义玲,宋文东. 硝酸益康唑微胶囊的制备及性能研究[J]. 广东药学院学报, 2006, 22(2): 121-122,129 |
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| 作者姓名： | 范润珍 万义玲 宋文东 |
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| 作者单位： | 广东海洋大学,理学院,广东,湛江,524025;广东海洋大学,理学院,广东,湛江,524025;广东海洋大学,理学院,广东,湛江,524025 |
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| 基金项目： | 广东海洋大学校内资助项目(0312057) |
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| 摘 要： | 目的对以明胶和阿拉伯胶为囊材制得的硝酸益康唑微胶囊的含量、稳定性、缓释特性进行研究。方法高效液相色谱法测定微胶囊的含量;采用经典方法,进行影响因素试验、加速试验来考察微胶囊的稳定性;采用渗透法,在相同条件下,测定硝酸益康唑栓剂和硝酸益康唑微胶囊的累积释放百分率。结果微胶囊载药量为36.47%;对光和单纯的高温具有较好的稳定性,在湿热条件下不稳定;与栓剂相比,硝酸益康唑微胶囊释放速度缓慢。结论硝酸益康唑微胶囊呈规则球形,性质稳定,具有明显的缓释特性。
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| 关 键 词： | 硝酸益康唑 微胶囊 缓释制剂 高效液相色谱法 |
| 文章编号： | 1006-8783（2006）02-0121-02 |
| 收稿时间： | 2006-01-16 |
| 修稿时间： | 2006-01-162006-03-26 |
Microcapsule characteristics of econazole nitrate |
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| FAN Run-zhen,WAN Yi-ling,SONG Wen-dong. Microcapsule characteristics of econazole nitrate[J]. Academic Journal of Guangdong College of Pharmacy, 2006, 22(2): 121-122,129 |
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| Authors: | FAN Run-zhen WAN Yi-ling SONG Wen-dong |
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| Affiliation: | Science College of Guangdong Ocean University, Zhanjiang 524025, China |
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| Abstract: | Objective To evaluate the content,stability and release of econazole nitrate in microcapsule consisted of gelatin and acacia.Methods The content of econazole nitrate in microcapsule was determined by HPLC.The stability of the microcapsule was evaluated by classical stress test and accelerated test.The overall release rates of econazole nitrate in the suppository and microcapsule were measured by osmosis.Results The content of econazole nitrate in the microcapsule was 36.47%.It was stabile under light radiation and higher temperature and unstable under higher humidity.Econazole nitrate in the microcapsule had a slower release rate than that in the suppository.Conclusion Econazole nitrate microcapsule is a uniform sphere and stable with remarkable sustained-release property. |
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| Keywords: | econazole nitrate microcapsule sustained release |
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