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大鼠一侧睾丸扭转对侧睾丸改变的实验研究
引用本文:姚启盛,叶章群,王晓康,易建华,张吉才,陈丛波. 大鼠一侧睾丸扭转对侧睾丸改变的实验研究[J]. 中华男科学杂志, 2003, 9(8): 586-588
作者姓名:姚启盛  叶章群  王晓康  易建华  张吉才  陈丛波
作者单位:1. 华中科技大学同济医学院附属同济医院泌尿外科,湖北,武汉,430030
2. 十堰市太和医院泌尿外科,湖北,十堰,442000
摘    要:目的 :研究一侧睾丸扭转 (UTT)后对侧睾丸组织学及生精细胞凋亡的改变 ,以明确UTT后对侧睾丸是否存在损伤。 方法 :SD雄性大鼠 6 0只 ,随机分为实验组 (n =4 8)及对照组 (n =12 )。实验组采用Turner方法建立左侧睾丸扭转模型 ,于扭转后 6h处死 4只 ,其余 4 4只再分为扭转睾丸复位及切除组 ,分别于术后 1d、1周、4周处死7~ 8只 ,取睾丸组织进行组织学及生精细胞凋亡的检测。 结果 :UTT复位后对侧睾丸组织学发生明显改变 ,生精细胞凋亡指数明显高于对照组 (P <0 .0 5 )。扭转睾丸切除后对侧睾丸变化不明显。 结论 :UTT可引起对侧睾丸损伤 ,其机制可能与再灌注有关 ,扭转睾丸切除可防止或减轻对侧睾丸的损伤

关 键 词:睾丸扭转  睾丸损伤  生精细胞  凋亡  大鼠
文章编号:1009-3591(2003)08-0586-03
修稿时间:2003-01-12

Experimental Study of Contralateral Testicular Changes after Unilateral Testicular Torsion in Rats
Qi Sheng YAO ,Zhang Qun YE ,Xiao Kang WANG ,Jian Hua YI ,Ji Cai ZHANG ,Cong Bo CHEN. Experimental Study of Contralateral Testicular Changes after Unilateral Testicular Torsion in Rats[J]. National journal of andrology, 2003, 9(8): 586-588
Authors:Qi Sheng YAO   Zhang Qun YE   Xiao Kang WANG   Jian Hua YI   Ji Cai ZHANG   Cong Bo CHEN
Affiliation:Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei 430022, China.
Abstract:OBJECTIVE: To study the changes of the contralateral testicular histology and germ cell apoptosis after unilateral testicular torsion (UTT) and to determine whether the contralateral testis is injured or not. METHODS: Sixty SD male rats were divided into control group (12 rats) and experimental group(48 rats). The former underwent sham operation of the left testis under general anaesthesia. The latter underwent left testis torsion(720 degrees) for 6 h, and then 4 of them were sacrificed and the other 44 were subdivided into the torsed testis untwisted group (22 rats) and the torsed testis removal group (22 rats), 7-8 rats were sacrificed and both testes (twisted and untwisted) were removed 1 day, 1 week and 4 weeks after surgery. All testes underwent histological and germ cell apoptosis examination. RESULTS: There were significant histological changes in the contralateral testis, and the germ cell apoptosis was increased greatly in the contralateral testis. CONCLUSIONS: UTT can cause contralateral testicular injury, whose mechanism may be related to reperfusion, and torsed testis removal can prevent or reduce damage to the contralateral testis.
Keywords:Testicular torsion  Testicular damage  Germ cell  Apoptosis  Rat
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