| 食用油烟对实验动物脂质过氧化和巨噬细胞膜脂流动性的影响 |
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| 引用本文： | 周亚美 张正东. 食用油烟对实验动物脂质过氧化和巨噬细胞膜脂流动性的影响[J]. 环境与健康杂志, 1997, 14(2): 64-66 |
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| 作者姓名： | 周亚美 张正东 |
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| 作者单位： | 南京医科大学环境医学研究室 |
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| 摘 要： | 为探讨食用油烟对巨噬细胞膜脂流动性的影响，选用ＳＤ大鼠于染毒柜中自然吸入食用豆油油烟，急性染毒，观察到油烟平均浓度为１．０５ｍｇ／ｍ＾３时，肺组织发生脂质过氧化，ＭＤＡ开始增加（Ｐ〈０．０５），平均浓度为９．５８ｍｇ／ｍ＾２，肺泡灌洗液中肺巨噬细胞脂膜流动性增加（Ｐ〈０．０１），且ＬＤＨ，ＡＣＰ酶的活力升高（Ｐ〈０．０５），吸入油烟浓度与各指标间有显著的剂量－反应关系。结果提示，食用油烟在本实验条
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| 关 键 词： | 食用油烟 巨噬细胞膜脂 脂质过氧化 动物 流动性 |
The Effect of Cooking Oil Vapors on Lipid Peroxidation and the Fluidity of Pulmonary Alveolar Macrophage Membranes in Rats |
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| Zhou Yamei,Zhang Zhengdong,Weng Niannong et al.Dept of Environmental Mcdicine,Nanjing Medical University,Nanjing. The Effect of Cooking Oil Vapors on Lipid Peroxidation and the Fluidity of Pulmonary Alveolar Macrophage Membranes in Rats[J]. Journal of Environment and Health, 1997, 14(2): 64-66 |
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| Authors: | Zhou Yamei Zhang Zhengdong Weng Niannong et al.Dept of Environmental Mcdicine Nanjing Medical University Nanjing |
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| Affiliation: | Zhou Yamei,Zhang Zhengdong,Weng Niannong et al.Dept of Environmental Mcdicine,Nanjing Medical University,Nanjing 210029 |
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| Abstract: | The S.D.Rats were selected to inhale the cooking bean oil vapor in the acute toxicity test so as to study the effect of cooking oil vapor on lipid fluidity of pulmonary alveolar macrophage(PAM) membrane.The bean oil vapor inhalation in average concentration 1.05mg/m 3 conductcd the lipid peroxidation of lung tissues in rats,and the malondialdehyde(MDA)increased significantly ( P <0 05).Up to the 9.58mg/m 3 in average,the lipid fluidity of pulmonary alveolar macrophage(PAM) membranes and the activities of lactate dehydrogenase(LDH) as well as acid phosphatase(ACP) in bronchoalveolar lavage fluid(BALF) also increased significantly( P< 0.01 and P< 0.05 respectively).The dose response relationship analysis revealed the values of all indexes were positive correlated to the oil vapor concentrations inhalted.These results suggested cooking oil vapor increased the lipid fluidity of PAM membranes. |
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| Keywords: | Cooking oil vapors Bronchoalveolar lavage fluid Pulmonary alveolar macrophage Lipid fluidity Lipid peroxidation |
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