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中药穴位注射治疗动眼神经麻痹多中心随机对照研究
引用本文：郭淑芹,任红,曹艳霞,王林. 中药穴位注射治疗动眼神经麻痹多中心随机对照研究[J]. 世界针灸杂志, 2013, 23(1): 9-14. DOI: 10.1016/S1003-5257(13)60003-3
作者姓名：郭淑芹  任红  曹艳霞  王林
作者单位：1. 保定市第一中心医院,河北保定071000,中国
2. 河北大学附属医院
3. 保定市第四医院
基金项目：Supported by designated project of 2008 Scientific Plan of TCM and Integrative Medicine of Hebei Administration of TCM:2008080
摘    要：
目的:评价中药穴位注射治疗动眼神经麻痹的临床疗效.方法:将3个中心的456例动眼神经麻痹患者随机分为穴位注射组和西药组各228例,穴位注射组采用中药穴位注射疗法,以患侧睛明、阳白、四白、瞳子髎、肝俞(双)为基础穴,复方当归注射液为主药,再据辨证分型配合相应的腧穴和注射药物;西药组常规西医治疗.每日治疗1次,10次为一疗程,疗程间休息3d,3个疗程后统计疗效.记录两组治疗前后的中医证候积分、眼球运动度、眼裂和瞳孔大小.结果:穴位注射组总有效率91.7％(209/228),西药组总有效率73.6％ (168/228),两组比较差异有统计学意义(P＜0.05);治疗后两组中医证候积分均较治疗前明显减少(P＜0.01,P＜0.05),穴位注射组的降低值较西药组更明显(P＜0.05);两组治疗后患眼眼球运动度、眼裂均有增加,瞳孔均缩小(均P＜0.05),穴位注射组眼球运动度内直肌的改善优于西药组,眼裂大于西药组(均P＜0.05).结论:中药穴位注射疗法治疗本病疗效确切,且效果优于常规西医治疗.
关 键 词：动眼神经麻痹  中药针剂  穴位注射  多中心随机对照试验

Multicenter randomly controlled trial on acupoint injection therapy with Chinese herbal medicines for oculomotor paralysis
GUO Shu-qin,REN Hong,CAO Yan-xia,WANG Lin. Multicenter randomly controlled trial on acupoint injection therapy with Chinese herbal medicines for oculomotor paralysis[J]. World Journal of Acupuncture-Moxibustion, 2013, 23(1): 9-14. DOI: 10.1016/S1003-5257(13)60003-3
Authors:GUO Shu-qin  REN Hong  CAO Yan-xia  WANG Lin
Affiliation:1.First Central Hospital of Baoding City,Baoding 071000,Hebei Province,China;2.Affiliated Hospital of Hebei University;3.Fourth Hospital of Baoding City ZHANG Yong-mei)
Abstract:
ObjectiveTo evaluate the clinical effect of acupoint injection therapy for paralysis of oculomotor nerve with Chinese herbal medicines.MethodsA total number of 456 patients from 3 centers with paralysis of oculomotor nerve were randomly divided into an acupoint injection group and a control group with 228 cases each. Patients in the acupoint injection group were treated with injection of Chinese herbal medicines to Jīngmíng (
></figure> BL 1), Yángbái (<figure class=></figure> GB 14), Sìbái (<figure class=></figure> ST 2), Tóngziliáo (<figure class=></figure> GB 1) on the affected side, and G?nshū (<figure class=></figure> BL 18) on both sides, Compound Angelica Injection was the main drug, and the corresponding acupoints and other injection drugs were also used according to differentiation of syndrome. Patients in the control group were treated with common western medicine. The treatment was given once a day, 10 times constituted one course with 3 days of interval. After 3 courses, the effect was assessed. TCM syndrome score, eyeball movement degree, the sizes of oculi rimae and pupil of the two groups were recorded before and after treatment.<b>Results</b>The effective rate of acupoint injection group was 91.7% (209/228), and that of the control group was 73.6% (168/228). There was statistical significance in comparing the difference between the two groups (<em>P</em><0.05). TCM syndrome scores of the two groups after the treatment became less obviously than those before the treatment (<em>P</em><0.01, <em>P</em><0.05), the score of acupoint injection group was more reduced than that of the control group (<em>P</em><0.05). Eyeball movement degree and oculi rimae were enlarged and the pupil reduced in the affected eye in both groups after the treatment (all <em>P</em><0.05). The musculus rectus medialis for the eyeball movement in the acupoint injection group was more improved than that of the control group, and the oculi rimae was bigger in the acupoint injection group than that in the control group (both <em>P</em><0.05).<b>Conclusion</b>Acupoint injection therapy with Chinese herbal medicines has assured effect on the treatment of oculomotor paralysis.</td> </tr> <tr> <td align=
Keywords:paralysis of oculomotor nerve  injection with Chinese traditional medicines  acupoint injection  multicenter randomized controlled trial
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