老年2型糖尿病患者超敏C反应蛋白与动脉硬化的相关性研究

目的：探讨老年2型糖尿病（T2DM）患者血清超敏C反应蛋白（hs2CRP）水平与动脉硬化的相关性。方法：选择T2DM患者60例，分为糖尿病斑块组30例（超声检查颈内动脉见斑块）和糖尿病非斑块组30例（超声检查颈内动脉未见斑块），对照组健康体检者30例，检测空腹血糖（FPG）、糖化血红蛋白（HbAlc）、血浆总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL—C），低密度脂蛋白胆固醇（LDL—C）和hs2CRP。结果：糖尿病斑块组与非斑块组患者的FPG、HbAlc、TC、TG、LDL—C水平均明显高于正常对照组（P〈0．05），HDL—C低于对照组（P〈0．05）；三组间的hs2CRP差异有统计学意义（P〈0．05），斑块组hs2CRP水平高于非斑块组，且均高于正常对照组（P〈0．05）。结论：hs2CRP与老年T2DM患者颈动脉硬化的发生有密切相关性，在老年T2DM颈动脉硬化的发展中起重要作用。

Correlation between Hypersensitivity C2-reactive Protein and Arterial Elasticity Disease in Type 2 Diabetes Mellitus

Objective： To investigate the association between serum high-sensitivity C-reactive protein （ hs2-CRP ） level and large arterial elasticity in patients with type 2 diabetes （ T2DM ） .Method： 60 T2DM were divided into two group： 30 patients with atherosclerosis disease, 30patients without atherosclerosis disease, and 30 healthy volnuteers were selected as control group, hs2CRP, body mass index （ BMI ）, triglyceride （ TG ）, total cholesterol （ TC ）, Highdensity Lipoprotein2cholesterol （ HDL2C ）, low density lipoprotein2 cholesterol （ LDL2C ）, glycosylat2ed hemoglobin （ HbAlc ） and fasting plasma glucose （ FPG ） were measured.Result： hs2CRP was significantly increased in T2DM group as compared with control levels.Hs2CRP was significantly increased in T2DM with atherosclerosis disease as compared with that inT2-DM without atherosclerosis group （ P〈0.05 ） .Univariate analysis implied that hs2CRP level in diabetes mellitus waspositively related with HbAlc, TC, TG, LDL-C （ P〈0.05 ） .Hs2CRP was negatively correlated with HDL-C （P〈0.05） .But there was no relationship between hs2CRP and BMI, FPG （P〈0.05） .Conclusion： Increase in Hs2CRP is closely correlated with atherosclerosis disease in type 2 diabetes mellitus, suggesting that hs2CRP plays an important role in risk prediction of the T2DM patients with atherosclerosis disease.