肿瘤标志物SCC-Ag、NSE、CYFRA21-1、CEA联合检测在肺癌诊断中的应用价值

目的探讨肿瘤标志物SCC．Ag、NSE、CYFRA21—1、CEA联合检测在肺癌诊断中的应用价值。方法选择我院42例经病理检查确诊的肺癌患者，设为癌症组，42例良性肺疾病患者作为良性组，42例健康体检者作为对照组，所有患者均采用化学发光法对血清SCC—Ag、NSE、CYFRA21-1、CEA联合检测，观察联合检测的敏感性和特别性。结果癌症组四种肿瘤标志物水平明显高于良性组与对照组，组间比较差异具有显著性P〈0．05。单一肿瘤标志物检测具有较高的特异性，但灵敏度及准确率不高，联合检测大大提高了灵敏度与准确性，联合检测与单一检测灵敏度与准确率比较差异具有显著性P〈0．05。结论肿瘤标志物SCC．Ag、NSE、CYFRA21—1、CEA联合检测可明显提高检出率，同时还可对肺癌患者进行病理分型，具有重要的临床价值。

Application of joint detection of tumor markers such as SCC Ag,NSE,CYFRA21-1,and CEA in the diagnosis of lung cancer

Objective To evaluate the application of joint detection of the tumor markers such as SCC Ag, NSE, CYFRA21-1, and CEA in the diagnosis of lung cancer. Method The study chose 42 patients with confirmed lung cancer as the cancer group, 4.2 patients with benign lung disease as the benign group, and 42 healthy people as the control group. All of the patients were given the joint detection of SCC Ag, NSE, CYFRA21-1, and CEA through chemoluminescence method. The sensitivity and the particularity were observed. Results The level of the 4 kinds of tumor markers was the highest in the cancer group with significant difference （P 〈 0. 05 ）. A single tumor marker showed a relatively high particularity but low sensitivity and accuracy, while the sensitivity and accuracy could be greatly improved by the joint detection （ P 〈 0. 05 ）. Conclusion The joint detection of SCC Ag, NSE, CYFRA21-1, and CEA can obviously increase the detectable rate and provide the important clinical data for the diagnosis of lung cancer as well.