多发性硬化168例临床分析

目的探讨多发性硬化（MS）的临床特点。方法综合分析168例多发性硬化患者的一般资料、病变部位、重要辅助检查及治疗方法。结果168例MS患者最常见的临床症状为肢体无力和感觉异常，其次为肌肉痉挛性疼痛、视力障碍、排便异常、共济失调，个别患者可有周围神经改变。实验室检查示：脑脊液蛋白水平和IgG指数增高最常见。磁共振（MRI）异常率高达90．98％。糖皮质激素治疗有效。结论MS是一种临床表现复杂、累及中枢神经系统白质多部位、病程表现多时相的自身免疫性疾病。根据临床特点，综合神经电生理、脑脊液免疫学及影像学检查能大大提高临床确诊率．茸中磁其据成像意义较大。

Clinical analysis of 168 patients with multiple sclerosis

Objective To study the clinical features of multiple sclerosis(MS).Methods The general clinical data,leision locations,results of important assistant examinations,treatment of 168 MS patients were synthetically analyzed.Results The most common symptoms were weakness and dysesthesia.Secondly,they were muscle spasm and pain,vision dysfunction,incontinence,and ataxia.The rare symptoms were peripheral neurological changes.Laboratory examinations:Protein and IgG-index levels in CSF were markedly high.MRI abnormal ratio were 90.98%.The administration of glucocorticoid was effective.Conclusion There are a variety of clinical symptoms in patients with MS which mainly affect the white matter of central neurological system and showed multiple focus and multiple-phase course.In addition to clinical features,neuroelectrophysiology,CSF immunology and imaging investigations altogether care can greatly increase the rate of clinical definite diagnosis.Among them,MRI is relatively more useful.