Synthesis of C-prenylated analogues of stilbenoid methyl ethers and their cyclic dihydrobenzopyranyl derivatives as potential anti-inflammatory agents |
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| Authors: | Hana Pizova Milan Malanik Karel Smejkal Michal Oravec Pavel Bobal |
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| Affiliation: | Department of Chemical Drugs, Faculty of Pharmacy, Masaryk University, Palackeho tr. 1946/1, 612 00 Brno Czech Republic.; Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, Palackeho tr. 1946/1, 612 00 Brno Czech Republic ; Global Change Research Institute of the Czech Academy of Sciences, Belidla 986/4a, 603 00 Brno Czech Republic |
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| Abstract: | ![]()
An efficient and versatile synthesis of the naturally occurring C-prenylated stilbenoid methyl ethers and their synthetic analogues is presented. The synthesis represents a six step convergent process including an optimised C-prenylation method. Furthermore, during the demethylation process, six new dihydro-benzopyranyl derivatives were obtained and isolated.An efficient and versatile synthesis of the naturally occurring C-prenylated stilbenoid methyl ethers and synthetic analogs has been developed. |
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