结核分枝杆菌的耐药性研究

目的研究临床分离结核分枝杆菌耐药性,为科学选择抗结核药物提供依据。方法采用病人标本分离培养和药敏试验方法,对617例结核分枝杆菌临床分离株进行耐药性调查。结果本医院2011年度从住院结核患者痰标本中分离到617株结核分枝杆菌,均进行了临床常用抗结核药物敏感试验。所分离的临床株结核分枝杆菌对异烟肼和利福喷叮的耐药率均超过31%;对利福平和链霉素的耐药率超过27%,对利福布叮、丁胺卡那霉素耐药率超过15%。结论该医院临床分离的结核分枝杆菌耐药率处于较高的水平,提示临床应根据药敏试验结果选择抗结核药物,控制耐药结核菌株的产生。

RESEARCH ON THE DRUG-RESISTANT OF Mycobacterium tuberculosis

Objective To investigate the drug-resistant of Mycobacterium tuberculosis(TB) isolated strains so as to guide the choice of anti-TB drugs.Methods Totally 617 isolated strains of M.tuberculosis were collected from hospitals and were cultured to detect the drug-resistant M.tuberculosis.Results Among the 617 isolated strains from sputum of hospitals in 2011,more than 31% were resistant to Isoniazid and Rifapentine,more than 27% were resistant to Rifampicin and Streptomycin and more than 15% were resistant to Rifabutin and Amikacin.Conclusion The hospitals drug-resistant rate of M.tuberculosis is at a high level.Selection of anti-TB drugs should be based on susceptibility testing results to control the generation of drug-resistant stains of M.tuberculosis.