首页 | 本学科首页   官方微博 | 高级检索  
     

早期鼻咽癌三维适形和常规外照射计划的剂量学评价
引用本文:罗伟 邓小武 卢泰祥. 早期鼻咽癌三维适形和常规外照射计划的剂量学评价[J]. 中德临床肿瘤学杂志, 2005, 4(5): 271-275. DOI: 10.1007/s10330-004-0336-y
作者姓名:罗伟 邓小武 卢泰祥
作者单位:广州中山大学肿瘤防冶中心放射治疗科,510060
基金项目:This project was supported by a grant from Guangdong Medical Research Foundation (No.A1999214).
摘    要:
目的利用三维治疗计划系统对早期鼻咽癌常规和三维适形放疗(3D CRT)计划作剂量学比较,评估不同照射方法剂量分布的差异,为今后指导临床治疗提供剂量学的依据。方法选择22例早期鼻咽癌患者,用三维治疗计划系统对每例患者分别作出常规和3D CRT计划设计,然后根据靶区覆盖率(V95)、正常组织受量(D50,D33和D5等)和正常组织并发症发生率(NTCP)比较这两种计划。结果剂量学比较表明,常规和3D CRT的PTVnx70、PTVnd160、PTVnx60、PTVnx50的V95分别为98.22%和99.98%(P=0.06)、98.41%和99.63%(P=1.00)、98.22%和99.98%(P=0.03)、98.85%和99.63%(P=0.02)。保护正常组织方面:在3D CRT和常规计划中,单侧腮腺的D50分别为51.91Gy和64.30Gy(P=0.00),单侧颞颌关节D50,49.98Gy和64.47Gy(P=0.00),脊髓D1cc,44.98Gy和48.09Gy(P=0.00)。结论3DCRT在亚临床靶区比常规方法有稍好的靶区覆盖率,3D CBT治疗早期鼻咽癌的优势在于给予靶区相似剂量分布的前提下。可以比常规方法减少某些正常组织器官如腮腺、颞颌关节等照射剂量,减少它们的NTCP。

关 键 词:鼻咽癌  三维治疗计划系统  外照射计划  剂量学
收稿时间:2004-12-07
修稿时间:2005-03-04

Dosimetric Evaluation of Three Dimensional Conformal and Conventional Treatment Plans of Early Untreated Carcinoma of Nasopharynx
Wei LUO,Xiaowu DENG,Taixiang LU. Dosimetric Evaluation of Three Dimensional Conformal and Conventional Treatment Plans of Early Untreated Carcinoma of Nasopharynx[J]. The Chinese-German Journal of Clinical Oncology, 2005, 4(5): 271-275. DOI: 10.1007/s10330-004-0336-y
Authors:Wei LUO  Xiaowu DENG  Taixiang LU
Affiliation:(1) Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, 510060 Guangzhou, China
Abstract:
Objective: Conventional external beam irradiation techniques for nasopharyngeal carcinomahave limitations, and improving external beam irradiation techniques is needed to enhance the curativerate. This study was designed to evaluate the difference in dose distribution of three dimensional conformalradiotherapy (3D CRT) and conventional treatment plan in early untreated nasopharyngeal carcinoma us-ing a three dimensional treatment planning system. Methods: Twenty-two patients with early untreatednasopharyngeal carcinoma were selected. Conventional and 3D CRT plans were made for each of them andcompared with respect to target volume coverage (V95),normal tissue sparing (D50, D33 and D5, etc), nor-mal tissue complication probability (NTCP). Results: The average volumetric dose comparison indicatedthat the V95 of PTVnx70 were 98.22% and 99.99% (P=0.06), and PTVnd60, 98.41% and 99.63% (P=1.00),PTVnx60, 98.44% and 99.98% (P=0.03 ), PTVnx50, 98.85% and 99.63% (P=0.02) in conventional and3DCRT treatment plans respectively. With respect to normal tissue sparing, the average D50 of unilateralparotid glands were 51.91 Gy and 64.30 Gy (P=0.00) respectively, and the unilateral temporomandibularjoints, 49.98 Gy and 64.47 Gy (P=0.00), the D1cc of spinal cords, 44.98 Gy and 48.09 Gy (P=0.00) in 3DCRT and conventional plans. Conclusion: Though only a little bit better dose coverage of target volumein subclinical lesion region was reached in 3D CRT plans, it spared more normal tissues e.g. parotid glandsand temporomandibular joints etc and decreased their NTCP while it got the similar dose distribution intarget volumes as conventional plans did for these early nasopharyngeal carcinoma cases.
Keywords:Nasopharyngeal carcinoma  3D TPS  External beam irradiation plan  Dosimetry
本文献已被 CNKI 维普 万方数据 SpringerLink 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号