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| PTCH在肾透明细胞癌中的表达及意义 | |
| 引用本文： | 梁波,李晓明,郭敏. PTCH在肾透明细胞癌中的表达及意义[J]. 辽宁医学院学报, 2012, 33(1): 5-6,97 |
| 作者姓名： | 梁波 李晓明 郭敏 |
| 作者单位： | 辽宁医学院组织学与胚胎学教研室,辽宁,锦州,121001 |
| 基金项目： | 辽宁省教育厅科技研究资助项目 |
| 摘 要： | 目的 观察肾透明细胞癌(Renal clear cell carcinoma,RCCC)及正常肾组织中PTCH 的表达,探讨RCCC中PTCH的异常表达与肾癌之间的关系.方法 采用免疫组化技术检测 RCCC 及正常肾组织中PTCH 蛋白的表达.结果 在正常肾组织中PTCH微量表达,而在RCCC中PTCH高表达,且其表达与患者的年龄、性别及肿瘤大小均无关.结论 Hedgehog信号通路中PTCH表达上调可能参与了RCCC的发病,其在肾细胞癌的发生、发展等方面可能具有重要作用. |
| 关 键 词： | 肾透明细胞癌 PTCH 免疫组化 免疫印迹法 |
Expression and Significance of PTCH in Renal Clear Cell Carcinoma |
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| LIANG Bo,LI Xiaoming,GUO Min. Expression and Significance of PTCH in Renal Clear Cell Carcinoma[J]. Journal of Liaoning Medical University (LNMU) Bimonthly, 2012, 33(1): 5-6,97 | |
| Authors: | LIANG Bo LI Xiaoming GUO Min |
| Affiliation: | (Department of Histology and Embryology,Liaoning Medical University,Jinzhou 121001 China) |
| Abstract: | Objective To observe the expression of PTCH in renal clear cell carcinoma(RCCC) and normal renal tissues,and to investigate the correlation between the abnormal expression of PTCH and RCCC.Methods Expression of PTCH was detected by immunohistochemistry in RCCC and normal kidney.Results Lower PTCH was expressed in normal kidney.Up-regulation of PTCH was observed significantly in RCCC.The increased PTCH level was disassociated with age,gender,and tumorous size of RCCC.Conclusions Up-regulation of PTCH in Hedgehog signaling pathway might be involved in RCCC,and it might have an important role in development and progression process of RCCC. |
| Keywords: | renal clear cell carcinoma PTCH immunohistochemistry western blotting |
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