| 73例系统性红斑狼疮患者淋巴细胞亚群分析 |
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| 引用本文： | 张德杰,向阳,黄世林.73例系统性红斑狼疮患者淋巴细胞亚群分析[J].检验医学与临床,2012,9(4):427-427,430. |
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| 作者姓名： | 张德杰 向阳 黄世林 |
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| 作者单位： | 解放军第二一○医院中医血液科,116021 |
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| 摘 要： | 目的 了解系统性红斑狼疮(SLE)患者外周血T淋巴细胞亚群、B细胞及自然杀伤细胞(NK细胞)的改变.方法 用流式细胞仪对73例SLE患者及25例健康女性的外周血淋巴细胞亚群进行检测.结果 与健康女性比较,97.3%的SLE患者存在淋巴细胞亚群的异常,以CD3+CD4+细胞减低(P<0.01),CD3+CD8+细胞增高(P<0.01),CD3+CD4+/ CD3+CD8+比值减低,多数倒置(P<0.01),CD19+细胞减少(P<0.05)尤为明显.结论 SLE患者免疫功能异常.
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| 关 键 词： | 红斑狼疮 系统性 淋巴细胞亚群 流式细胞术 |
Analysis of lymphocyte subsets in 73 patients with systemic lupus erythematosus |
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| ZHANG De-jie,XIANG Yang,HUANG Shi-lin.Analysis of lymphocyte subsets in 73 patients with systemic lupus erythematosus[J].Laboratory Medicine and Clinic,2012,9(4):427-427,430. |
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| Authors: | ZHANG De-jie XIANG Yang HUANG Shi-lin |
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| Institution: | (Department of Chinese Medicine Hematology,210 Hospital of PLA,Dalian,Liaoning 116021,China) |
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| Abstract: | Objective To investigate the changes of T lymphocyte subsets,B cells and natural killer cells（NKcells） of peripheral blood in the patients with systemic lupus erythematosus（SLE）.Methods Lymphocyte subsets of peripherial blood in 73 cases of SLE and 25 healthy famale controls were tested with flow cytometry.Results Compared with the female control group,97.3% cases of SLE reveled the lymphocyte subsets abnormality.CD3＋CD4＋cells were significantly decreased（P0.01）,CD3＋CD8＋ cells were significantly increased（P0.01）,CD3＋CD4＋/CD3＋CD8＋ ratio was decreased and inverted（P0.01）,CD19＋ cells were significantly decreased（P0.05）.Conclusion Immunologic function is abnomal in SLE patients. |
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| Keywords: | lupus erythematosus systemic lymphocyte subsets flow cytometry |
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