止呕散穴位贴敷防治顺铂所致消化道反应的临床观察

目的 探讨止呕散外敷穴位加昂丹司琼与单用昂丹司琼在预防肺癌顺铂化疗后恶心呕吐的效果.方法 选取"GP"或"NP"方化疗的非小细胞肺癌共80例,随机分为对照组与治疗组,每组各40例.对照组常规化疗,止吐药选择昂丹司琼;治疗组在对照组基础上,加用由半夏、吴茱萸、生姜等组成的止呕散贴敷患者双侧内关穴、梁门穴和足三里穴,每日更换,21 d为一个观察周期.结果 治疗组控制恶心症状有效率为90.0%,完全控制率为57.5%;控制呕吐症状有效率为92.5%,完全控制率为72.5%;对照组控制恶心症状有效率为72.5%,完全控制率为30.0%;控制呕吐症状有效率为77.5%,完全控制率为40.0%;两者差异有统计学意义(P＜0.05).结论 穴位贴敷治疗可有效防治顺铂所致消化道反应.

The Clinical Observation of Applying Acupoint with Vomitting-arresting Pulvis to Prevent and Treat Gastrointestinal Tract Reaction Caused by Cis-platinum Complexes

Objective To compare the effect of applying acupoint with Vomitting-arresting pulvis plus Ondansetron and Ondansetron only to prevent and treat nausea and vomitting caused by cis-platinum complexes in non-small-cell-lung-cancer.Methods 80 non-small-cell-lung-cancer patients treated by"GP"or "NP" chemotherapy treatment plan were divided into two groups randomly and averagely: the control group received general chemotherapy treatment,and chose Ondansetron as antemetic.On the base of the control group,the treatment group took Vomitting-arresting pulvis to apply unilateral Neiguan point,Liangmen point and Zusanli point,instead everyday and alternating from left to right.Results In the treatment group,the effective rate of controlling nausea was 90.0%,the complete control rate was 57.5%;and the effective rate of controlling vomiting was 92.5%,the complete control rate was 72.5%.And in the control group,the effective rate of controlling nause was 72.5%,the complete control rate was 30.0%;and the effective rate of controlling vomiting was 77.5%,the complete control rate was 40.0%.There was a significant difference between two groups.Conclusion Applying acupoint with Vomitting-arresting pulvis could effectively prevent and treat gastrointestinal tract reaction caused by cis-platinum complexes.