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| 核转录因子Gli1在肾透明细胞癌中的表达及意义 | |
| 引用本文： | 李卫巍,李晓明. 核转录因子Gli1在肾透明细胞癌中的表达及意义[J]. 辽宁医学院学报, 2012, 33(1): 9-11,98 |
| 作者姓名： | 李卫巍 李晓明 |
| 作者单位： | 1. 辽宁医学院组织学与胚胎学教研室;锦州市妇婴医院,辽宁,锦州,121001 2. 辽宁医学院组织学与胚胎学教研室 |
| 基金项目： | 辽宁省教育厅科技研究资助项目 |
| 摘 要： | 目的 观察肾透明细胞癌(Renal clear cell carcinoma,RCCC)及正常肾组织中Gli1 的表达,探讨RCCC中Gli1的异常表达与肾癌之间的关系.方法 采用免疫组化技术检测 RCCC 及正常肾组织中Gli1 蛋白的表达.结果 在正常肾组织中Gli1不表达,而在RCCC中Gli1高表达,且其表达与患者的年龄、性别及肿瘤大小均无关.结论 Hedgehog信号通路中Gli1表达上调可能参与了RCCC的发病,其在肾细胞癌的发生、发展等方面可能具有重要作用. |
| 关 键 词： | 肾细胞癌 Gli1 免疫组化 |
Expression and Significance of Gli1 in Renal Clear Cell Carcinoma |
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| LI Weiwei,LI Xiaoming. Expression and Significance of Gli1 in Renal Clear Cell Carcinoma[J]. Journal of Liaoning Medical University (LNMU) Bimonthly, 2012, 33(1): 9-11,98 | |
| Authors: | LI Weiwei LI Xiaoming |
| Affiliation: | 1(1.Department of Histology and Embryology,Liaoning Medical University; 2.Jinzhou Women and Children’s Hospital,Jinzhou 121001 China) |
| Abstract: | Objective To observe the expression of Gli1 in renal clear cell carcinoma(RCCC) and normal renal tissues,and to investigate the correlation between the abnormal expression of Gli1 and RCCC.Methods Expression of Gli1 was detected by immunohistochemistry in RCCC and normal kidney.Results Gli1 was not expressed in normal kidney.Up-regulation of Gli1 was observed significantly in RCCC.The increased Gli1 level was disassociated with age,gender,and tumorous size of RCCC.Conclusions Up-regulation of Gli1 in Hedgehog signaling pathway might be involved in RCCC,and it might have an important role in development and progression process of RCCC. |
| Keywords: | renal cell carcinoma Gli1 immunohistochemistry |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |