GLP-1与2型糖尿病及糖尿病肾病的相关性研究

目的 探讨2型糖尿病者(T2DM)和健康对照者(NC),糖尿病肾病者(DN)和糖尿病非肾病者(NDN)血浆胰高血糖素样肽-1(GLP-1)水平的差异.方法 选择144例云南汉族人群为研究对象,包括2型糖尿病患者86例其中55例糖尿病无肾病(NDN),30例糖尿病肾病(DN)],为T2DM组,健康对照者59例,为NC组.采用EIA法测定空腹GLP-1浓度,比较不同组别之间血浆GLP-1水平的差异.结果 T2DM患者空腹血浆GLP-1浓度低于NC者,(3.83±6.84) pmol/L vs (2.78±2.95) pmol/L,P＜0.05];NDN患者与DN患者空腹血浆GLP-1浓度差异无统计学意义(2.68±2.57) pmol/L vs (2.96±3.58) pmol/L,P＝0.665].血浆GLP-1水平与HDL-C呈正相关,与年龄呈负相关.结论 血浆GLP-1水平的降低可能是2型糖尿病的危险因素,而GLP-1水平增高有可能在2型糖尿病患者大血管并发症的发生中发挥作用.年龄的增长引起GLP-1浓度下降可能为T2DM的发病机制之一.

Association of GLP-1 with Type 2 Diabetes Mellitus and Diabetic Nephropathy

Objective To investigate the plasma concentration of Glucagon-Like Peptide 1(GLP-1)in type 2 diabetes patients(T2DM),normal controls(NC),diabetic nephropathy(DN)and diabetic non-nephropathy(NDN).Methods We recruited 86 T2DM patients in Yunnan Han population(including 55 NDN cases and 30 DN cases)and 59 normal controls(NC group).Fasting plasma level of GLP-1 was measured by Enzyme linked immunosorbent assay(EIASA)method.Results T2DM patients had significant lower GLP-1 level than controls(3.83 ± 6.84) pmol/l vs(2.78 ± 2.95) pmol/l,P = 0.025].The difference of the fasting plasma GLP-1 between NDN and DN patients was not statistically significant(2.68 ± 2.57) pmol/l vs(2.96 ± 3.58) pmol/L,P = 0.665].GLP-1 level was positively correlated with HDL-C and was negatively correlated with age.Conclusions Fasting plasam GLP-1 level might be a risk factor for T2DM.GLP-1 level may play a role in the pathogenesis of macrovascular complications in T2DM.Aging-related reduced GLP-1 may be one of the pathway involving in T2DM.