| 甲基阿魏酸对PDGF—BB刺激的肝星状细胞增殖的影响 |
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| 引用本文： | 容明智,李丽,李勇文,唐春燕,庞文肖,程钰. 甲基阿魏酸对PDGF—BB刺激的肝星状细胞增殖的影响[J]. 右江民族医学院学报, 2012, 34(6): 738-739 |
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| 作者姓名： | 容明智 李丽 李勇文 唐春燕 庞文肖 程钰 |
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| 作者单位： | 桂林医学院,广西桂林,541004 |
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| 基金项目： | 广西医科大学开放实验室项目 |
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| 摘 要： | 目的观测甲基阿魏酸(meth-ferulic acid,MFA)对PDGF-BB刺激的肝星状细胞(HSC-T6)增殖的影响。方法采用四甲基噻唑蓝(MTT)法检测MFA对HSC-T6增殖的影响并计算抑制率。结果 MFA可以抑制HSC的增殖,呈现一定的剂量依赖性。结论 MFA能抑制PDGF-BB刺激HSC的增殖作用从而减轻肝纤维化。
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| 关 键 词： | 甲基阿魏酸 肝星状细胞 细胞增殖 肝硬化 |
The effects of MFA on PDGF-BB-induced hepatic satellite cells proliferation |
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| RONG Ming-zhi , LI Li , LI Yong-wen , TANG Chun-yan , PANG Wen-xiao , CHENG-yu. The effects of MFA on PDGF-BB-induced hepatic satellite cells proliferation[J]. Journal of Youjiang Medical College For Nationalities, 2012, 34(6): 738-739 |
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| Authors: | RONG Ming-zhi LI Li LI Yong-wen TANG Chun-yan PANG Wen-xiao CHENG-yu |
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| Affiliation: | (Guilin Medical University,Guilin,Guangxi 541004,China) |
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| Abstract: | Objective To study the influence of(meth-ferulic acid,MFA) on proliferation of PDGF-BB-induced hepatic satellite cells(HSC-T6).Methods The proliferation of HSC-T6 was detected by MTT assay and the inhibitory rate was calculated.Results MFA could inhibit the proliferation of HSC,presenting a certain degree of dose-dependent state.Conclusion MFA can inhibit the PDGF-BB-induced proliferation of HSC,so that reducing hepatic fibrosis. |
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| Keywords: | meth-ferulic acid hepatic satellite cell cell proliferation liver fibrosis |
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