C型凝集素受体对固有免疫应答的双向调节作用

C型凝集素受体（CLR）是模式识别受体家族中有别于TLR的新家族，在机体免疫应答中发挥着重要作用。近年来，人们对CLR对固有免疫应答的调节作用进行了较为广泛的研究，越来越多的研究发现CLRs对固有免疫应答具有双向调节作用：不同的CLR在固有免疫应答中既可以发挥正性调节作用，也能够发挥负性调节作用；在针对不同的病原体或在抗原提呈细胞不同的成熟状态等条件下，同-CLR在固有免疫应答中也可以发挥正负调节两方面的作用。深入探讨CLR对固有免疫应答的双向调节作用，对于进一步理解免疫应答的精细调节及疾病发病机制的复杂性等都有重要的理论意义，同时也为许多疾病的预防与治疗提供了一种新的策略。

Two-way regulation of C-type lectin receptors on innate immune response

C-type lectin receptors (CLR), which play an important role in the immune response, are a new family of pattern recognition receptors. Accumulating data showed that the innate immune response could be regulated by CLRs by an two-way manner. Both positive and negative regulations on innate immune response could be induced by different CLRs. Furthermore, the same CLR could also regulate the innate immunity positively and negatively depending on recognizing different pathogens or on the maturation states of antigen presenting cells. Further studies on the two-way regulation of CLRs on innate immunity could facilitate our understanding of the subtle regulation of immune response and the complexity of disease pathogenesis, and may help us in the prevention and clinical therapy of many diseases.