心肌梗塞大鼠心室胶原生化改建与心脏肾素—血管紧张素系统的关系

目的 研究心肌梗塞（MI）后心室胶原生化改建与心脏肾素-血管紧张素系统（RAS）的关系。方法 采用放射免疫等方法动态观测了大鼠MI后3、15及42天左、右心室胶原含量、总量和血管紧张素Ⅱ(AngⅡ）含量以及血浆AngⅡ含量的变化，结果 血浆AngⅡ含量仅在MI后3天有一过性升高；MI鼠左、右心室AngⅡ含量以及血浆AngⅡ含量的变化。结果 血浆AngⅡ含量仅在MI后3天有一过性升高；MI鼠左、右心室AngⅡ含量于3天时就明显升高，此后一直保持在3天时水平，MI后左、右心室胶原基质均发生了生化改建，除右心室胶原生化建建稍滞后于其AngⅡ的变化外，左、右心室的胶原生化改建与其心肌AngⅡ的变化形式基本一致。结论 MI后心脏RAS被明显激活；心肌AngⅡ在心肌胶原生化改建的过程中可能起着重要的作用。而且其作用不依赖于循环RAS。

Biochemical remodeling of myocardial collagen and its relation to cardiac renin-angiotensin system in rats after myocardial infarction]

OBJECTIVE: This study aimed at the biochemical remodeling of myocardial collagen and its relation to cardiac renin-angiotensin system (RAS) after myocardial infarction(MI). METHODS: The ventricular and plasma angiotensin II (Ang II) content, total collagen content, and collagen concentration in left ventricle(LV) and right ventricle(RV) of MI and sham-operated control(SOC) rats on 3, 15 and 42 days after operation were measured dynamically by means of radioimmunoassay etc. RESULTS: The plasma Ang II content increased only in MI rats on day 3. The Ang II content in LV of the MI group increased markedly on day 3 after MI as compared with that of the SOC group. It sustained at this higher level on the 15th and 42th days, and the similar changes were observed in RV as well. The biochemical remodeling of collagen in LV and RV occurred after MI and the remodeling of collagen showed similar patterns with its Ang II content, except that collagen remodeling in RV was delayed than the change of Ang II content. CONCLUSION: The cardiac RAS was obviously activated after MI. Ventricular Ang II might play an important role in the biochemical remodeling of myocardial collagen, and its role was independent of circulating RAS.