利福平注射液-胶囊治疗复治菌阳肺结核疗效观察

目的观察复治菌阳的肺结核患者应用利福平针荆与利福平胶囊进行治疗的对比效果。方法160例复治菌阳肺结核患者A组应用HZES与利福平针剂进行治疗，B组应用HZES与利福平胶囊单纯口服的方案进行治疗。结果A组患者治疗2个月的痰菌阴转率同B组相较，差异均显著（P〈0．05）；A组患者治疗2个月胸部x线片改善的显效率同B组相较，差异均显著（P〈0．05）；结论复治菌阳的肺结核患者应用抗结核化疗与利福平针剂以及胶囊联合进行治疗，不仅起效快，而且副反应较少，应予推广。

Observation of the curative effect of rifampicin injection-capsule in the sequential treatment of patients with bacterium positive retreated pulmonary tuberculosis

Objective To observe the curative effect of rifampicin injection-capsule in the sequential treatment of patients with bacterium positive retreated pulmonary tuberculosis. Methods 160 patients with bacterium positive retreated pulmonary tuberculosis from November 2008 to November 2011 were divided into two groups, and their clinical data were retrospectively analyzed. The group A were given the sequential treatment of HZES and rifampicin injectlon-capsule, and the group B were treated with HZES and rifampicin injec- tion. The sputum conversion, absorption of lung lesions and toxicity were observed and compared at the end of 2-month follow-up. Results The sputum negative conversion rates, the improvement of chest X-ray and the minification of cavity closure in the group A at the end of first and second month showed significant difference while compared with the group B （ P 〈 0. 05 ）, but the incidence difference of hepatic dysfunction between the two groups had no statistical significance （ P 〉 0.05 ）. Besides, the difference of gastrointestinal reaction showed a g significant difference （ P 〈 0. 05 ）. Conclusion The use of anti-tuberculous chemotherapy and rifampicin injection-capsule has a pref- erable and fast curative effect and little side-effect in the sequential treatment of patients with bacterium positive retreated pulmonary tuber-culosis. Besides, it is easier to be controlled and has shorter discharge time of bacteria. Thus, it has an important clinical value in reduc- ing the side effects and rescue of severe TB.