胰腺内分泌肿瘤外科诊治现状及进展

目的 探讨胰腺内分泌肿瘤外科诊断及治疗新进展.方法 搜集有关胰腺内分泌肿瘤相关文献并进行复习.结果 胰腺内分泌肿瘤可以过量分泌激素而引起相关临床症状.由于发病率低、临床症状复杂,常引起胰腺内分泌肿瘤的漏诊和误诊.最近影像学的进展及对血清激素水平的检测提高了胰腺内分泌肿瘤的早期诊断率.随着对胰腺内分泌肿瘤的了解及对其分子遗传机理的研究,其临床治疗观念也发生了重大变化.结论 正确诊断是胰腺内分泌肿瘤治疗的前提.外科干预仍是目前胰腺内分泌肿瘤治疗的首选方案,可以延长患者生存时间,改善和控制临床症状.

Present and Advance in Surgical Diagnosis and Treatment of Pancreatic Endocrine Tumors

Objective To approach the recent advances in diagnosis and surgical treatment of pancreatic endocrine tumors(PETs).Methods Articles relevant to diagnosis and treatment of PETs were collected and reviewed.Results PETs are characterized by their ability to over-produce peptides and hormones,which cause specific clinical syndromes.Because of rare incidence and complex clinical syndromes,there are still impediments to early diagnosis of these tumors.Monitoring of serum hormones and imaging method allow early tumor detection.PETs have been investigated for the past several decades.With the great knowledge of these tumors in molecular genetic level,clinical managements have been greatly changed.Conclusions Avoiding misdiagnosis is important for treatment of PETs.Surgical approach is still considered as the preferred option for curtailing the malignant progression of PETs and controlling the associated biochemical syndromes.