局部亚低温联合依达拉奉治疗急性脑梗死疗效观察

目的观察头颅局部亚低温联合依达拉奉治疗急性脑梗死的疗效。方法将发病72 h内的急性脑梗死患者58例分为治疗组和对照组,对照组仅用常规药物治疗,治疗组在常规药物治疗基础上加头颅局部亚低温联合依达拉奉治疗。在治疗前及治疗后10 d、30 d时评定患者欧洲卒中评分(ESS)和日常生活活动能力(ADL),90 d时评定ADL。结果30 d时治疗组ESS和ADL的增分率明显高于对照组(P<0.01)。90 d时治疗组ADL的增分率明显高于对照组(P<0.001)。治疗组的有效率显著高于对照组(P<0.001)。结论头颅局部亚低温联合依达拉奉治疗急性脑梗死比常规药物治疗更有效。

Observation of the effect of local mild hypothermia combined with Edaravone on acute cerebral infarctions

Objective It is to observe the therapeutic effect of local mild hypothermia combined with Edaravone on acute cerebral infarction(ACI).Methods 58 cases of patients with ACI within 72 hours of onset were randomly divided into therapy group and control group.The controlled group was only treated with routine drugs.The therapy group was treated with local mild hypothermia combined with Edaravone on the base of routine drugs.Before treatment,the 10th and 30th day after treatment,activity of daily living(ADL) and European Stroke Scale(ESS) were evaluated respectively,and ADL were evaluated on the 90th day.Results On the 30th day the increase rate of ESS and ADL in the therapy group were significantly higher than that in control group.On the 90th day the increase rate of ADL in the therapy group was higher than that in control group(P<0.001). The effective rate in the therapy group was higher than that in the control group(P<0.001).Conclusion The treatment with local mild hypothermia combined with Edaravone for ACI is more effective than normal drugs.