充血性心力衰竭患儿血清甲状腺激素水平的变化及意义

目的 探讨小儿充血性心务衰竭（ＣＨＦ，简称心衰）时血清甲状腺激素水平的变化及意义。方法 用放射免疫法分别测定６２例ＣＨＦ患儿心衰急性期、恢复期及３６例正常对照组血清三碘甲状腺原氨酸（Ｔ３）、四碘 甲状腺原氨酸（Ｔ４）、促甲 腺激素（ＴＳＨ）、反三碘甲状腺原氨酸（ｒＴ＃）及Ｔ３与ｒＴ３的比值（Ｔ３／ｒＴ＃）。结果 ＣＨＦ组急性期与对照组比较：Ｔ３明显下降，Ｐ〈０．０５；ｒＴ３显著升高、Ｔ３／ｒＴ３显

Change and significance of serum thyroid hormone in children with congestive heart failure

Objective To study the change and significance of serum thyroid hormone in children with congestive heart failure(CHF).Methods Serum triiodothyronine(T 3), tetraiodothyronine(T 4), thyroid stimulating hormone(TSH), reverse T 3(rT 3) levels, and the ratio of T 3/rT 3 were detected with immunoradiometric assay in 62 CHF patients at the acute stage and recovery stage, and in 36 normal children, respectively.Results In the acute stage of CHF, the serum T 3,T 3/rT 3 decreased and rT 3 increased significantly( P <0 01) than in control group, but T 4 and TSH were not significantly different from controls. The more serious the CHF, The lower T 3, T 3/rT 3 levels, and the higher rT 3 levels ( P <0 01).In addition, T 4 decreased significantly in the serious CHF patients ( P <0 01) and did not change in the mildor moderate CHF patients. In the recovery stage, T 3 and T 3/rT 3 increased significantly ( P <0 05, P <0 01) and rT 3 decreased significantly ( P <0 01).Conclusion In the acute stage of CHF, serum T 3, T 3/rT 3 decrease and rT 3 increase, while T 4 does not change in the severe patients. The determination of serum thyroid hormone is important in studying the pathogenesis of CHF and estimating prognosis.