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Autophagy： a double-edged sword for neuronal survival after cerebral ischemia |
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| Authors: | Wenqi Chen ;Yinyi Sun ;Kangyong Liu ;Xiaojiang Sun |
| Institution: | [1]Department of Neurology, the Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China; [2]Zhoupu Hospital, Pudong New District, Shanghai, China |
| Abstract: | Evidence suggests that autophagy may be a new therapeutic target for stroke, but whether activation of autophagy increases or decreases the rate of neuronal death is still under debate. This review summarizes the potential role and possible signaling pathway of autophagy in neuronal survival after cerebral ischemia and proposes that autophagy has dual effects. |
| Keywords: | nerve regeneration autophagy lysosome autophagosome neuron cerebral ischemia signaling pathway apoptosis necrosis survival NSFC grant neural regeneration |
| 本文献已被 CNKI 维普 等数据库收录！ | |