未成熟网织红细胞分数对评估30例造血干细胞移植效果的分析

目的探讨采用未成熟网织红细胞分数(IRF)监测造血干细胞移植(HSCT)患者造血功能恢复的临床价值。方法采用Sysmex XE-2100全自动血细胞分析仪检测30例白血病患者HSCT后的WBC、PLT、中性粒细胞绝对计数(ANC)、网织红细胞百分比(RET%)及IRF,并对结果进行对比分析。结果 30例患者移植后IRF、ANC、RET%、WBC、PLT分别在16.5、18.5、19.0、21.0、26.0d达到恢复指标。有93.3%(28/30)的患者IRF最早达到造血功能恢复的指标。IRF达到造血功能恢复指标的时间要早于WBC、PLT、ANC及RET%(P<0.05)。ANC及RET%达到造血功能恢复指标的天数要早于WBC及PLT(P<0.05)。ANC与RET%间比较差异无统计学意义(P>0.05)。结论 IRF是HSCT后造血功能恢复较敏感的指标,可用于HSCT后造血功能恢复的监测、病情观察及指导临床治疗。

Analysis on immature reticulocyte fraction for evaluating transplantation effect in 30 cases of hematopoietic stem cell transplantation

Objective To investigate the clinical value of immature reticulocyte fraction(IRF) in evaluating the recovery of blood-producing function after hematopoietic stem cell transplantation(HSCT).Methods To compare the detection results of WBC,PLT,ANC,RET% and IRF from 30 cases of hematopoietic stem cell transplantation by Sysmex XE-2100 automated hematology analyzer.Results IRF,ANC,RET%,WBC and PLT in 30 cases reached to the recovered indicators on 16.5,18.5,19.0,21.0,26.0 d.IRF in 93.3%(28/30) of cases reached the recovered the indicator of hematopoiesis function at the earliest.The days of recovery of IRF was earlier than WBC,ANC,RET% and PLT(P<0.05).The days of recovery of ANC and RET% were earlier than WBC and PLT(P<0.05),but the difference between the days of recovery of ANC and RET% had no statistical significance(P>0.05).Conclusion IRF is an early indicator of hemopoietic recovery after HSCT and can be applied to monitor hemopoietic recovery after HSCT,observe the disease condition and guide the clinical treatment.