| SQA鳌合盐的急性毒性和致突变性研究 |
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| 引用本文： | 黄海雄,张锦周,慈捷元,吴丽明,刘丽清. SQA鳌合盐的急性毒性和致突变性研究[J]. 职业与健康, 2005, 21(2): 176-177 |
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| 作者姓名： | 黄海雄 张锦周 慈捷元 吴丽明 刘丽清 |
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| 作者单位： | 广东省深圳市疾病预防控制中心,518020 |
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| 摘 要： | 目的 检测稀土壳糖胺(SQA)鳌合盐的急性毒性和致突变性。方法 采用霍恩氏法进行急性经口毒性试验，采用小鼠骨髓嗜多染红细胞微核试验、小鼠精子畸形试验和Ames试验对受试物进行致突变性研究。结果 SQA鳌合盐的经口LD50＞10000mg／kg体重；小鼠骨髓嗜多染红细胞微核试验显示无诱发微核作用，小鼠精子畸形试验未见精于畸形率增高，Ames试验在加和不加S9条件下均无致突变性。结论 SQA鳌合盐属实际无毒级物质，在该实验条件下，无致突变作用。
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| 关 键 词： | SQA鳌合盐 急性毒性 致突变性 微核 精子 Ames试验 |
| 文章编号： | 1004-1257(2005)02-0176-02 |
| 修稿时间： | 2004-08-10 |
Study on the Acute Toxicity and Mutagenesis of SQA |
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| HUANG Haixiong,ZHANG Jinzhou,CI Jieyuan,etc.. Study on the Acute Toxicity and Mutagenesis of SQA[J]. Occupation and Health, 2005, 21(2): 176-177 |
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| Authors: | HUANG Haixiong ZHANG Jinzhou CI Jieyuan etc. |
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| Abstract: | To study the acute toxicity and of SQA. Oral acute toxicity test was carried out according to Horns method; micronucleus test, sperm deformation test and Ames test were carried out for mutagenic observation. SDA oral LD 50 > 10 000 mg/kg; micronucleus test indicated no mutagenic effects; no increase in sperm deformation was found in sperm deformation test; Ames test showed no mutagenic effects under the condition of both with and without S9. [Conclusion] SQA belongs to nontoxic compound and has no mutagenic effects under certain experimental condition. |
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| Keywords: | SQA Acute toxicity Mutagenesis Micronucleus Sperm Ames test |
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