| 自身抗体阴性的原发性干燥综合征行唇腺活检的临床分析 |
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| 引用本文： | 唐晓航,于鹏,白志伟,祁劲松,曹经一. 自身抗体阴性的原发性干燥综合征行唇腺活检的临床分析[J]. 中国医药, 2011, 6(3): 353-354. DOI: 10.3760/cma.j.issn.1673-4777.2011.03.045 |
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| 作者姓名： | 唐晓航 于鹏 白志伟 祁劲松 曹经一 |
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| 作者单位： | 首都医科大学附属北京朝阳医院口腔科,100020 |
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| 摘 要： | 目的 探讨如何提高自身抗体(抗SSA/SSB抗体)阴性原发干燥综合征(pSS)患者唇腺活检诊断的刚性率.方法 回顾性分析82例抗SSA/SSB抗体阴性疑似pSS患者,行同位素检查腮腺受损情况和进行唇腺活检进行确诊情况.结果 82例患者唇腺活检病理报告阳性51例(62.2%),其中ChisholmⅢ级17例,Ⅳ级34例.51例唇腺活检阳性组中有44例(86.3%)腮腺同位素检查为中度以上受损;31例唇腺活检阴性组中有15例(48.4%)腮腺同位素检查为中度以上受损;2组之间差异有统计学意义(P＜0.01).结论 腮腺同位素检查受损在中度以上者,唇腺活检对自身抗体阴性pSS诊断的阳性率较高.Abstract：Objective To improve the diagnosis postive rate of primary Sjogren's syndrome (pSS) by labial salivary gland(LSG) biopsy in patients with negative autoantibodies(SSA/SSB autoantibodies). Methods Eightytwo suspected pSS inpatients with both negative SSA/SSB autoantibodies were analyzed retrospectively. The decreased parotid gland function was tested and the LSG biopsy was performed to confirmed diagnosis. Results There were fifty-one patients(62.2% ) were LSG biopsy positive, including 17 Chisholm Ⅲ and 34 Chisholm Ⅳ in histopathologic grading. And 44(86% ) were found Parotid gland function moderate/severe damaged in the 51 LSG positive patients, moreover 15(48% ) patients were found moderate/severe damaged in 31 LSG negtive patients, A chi-square test was used between the two groups, the difference was significant ( P ＜ 0.01 ), Conclusion LSG biopsy might be sensitive in suspected pSS patients with negtive antoantibodies when the parotid gland function is moderate/severe damaged.
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| 关 键 词： | 干燥综合征 唇腺活检 自身抗体 |
Clinical analysis of labial salivary gland biopsy for primary Sjogren's syndrome with negative autoantibodies |
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| TANG Xiao-hang,YU Peng,BAI Zhi-wei,QI Jin-song,CAO Jing-yi. Clinical analysis of labial salivary gland biopsy for primary Sjogren's syndrome with negative autoantibodies[J]. China Medicine, 2011, 6(3): 353-354. DOI: 10.3760/cma.j.issn.1673-4777.2011.03.045 |
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| Authors: | TANG Xiao-hang YU Peng BAI Zhi-wei QI Jin-song CAO Jing-yi |
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| Affiliation: | TANG Xiao-hang(Department of Stomatology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China) YU Peng(Department of Stomatology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China) BAI Zhi-wei(Department of Stomatology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China) QI Jin-song(Department of Stomatology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China) CAO Jing-yi(Department of Stomatology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China) |
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| Abstract: | Objective To improve the diagnosis postive rate of primary Sjogren's syndrome (pSS) by labial salivary gland(LSG) biopsy in patients with negative autoantibodies(SSA/SSB autoantibodies). Methods Eightytwo suspected pSS inpatients with both negative SSA/SSB autoantibodies were analyzed retrospectively. The decreased parotid gland function was tested and the LSG biopsy was performed to confirmed diagnosis. Results There were fifty-one patients(62.2% ) were LSG biopsy positive, including 17 Chisholm Ⅲ and 34 Chisholm Ⅳ in histopathologic grading. And 44(86% ) were found Parotid gland function moderate/severe damaged in the 51 LSG positive patients, moreover 15(48% ) patients were found moderate/severe damaged in 31 LSG negtive patients, A chi-square test was used between the two groups, the difference was significant ( P ＜ 0.01 ), Conclusion LSG biopsy might be sensitive in suspected pSS patients with negtive antoantibodies when the parotid gland function is moderate/severe damaged. |
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| Keywords: | Sjogren's syndrome LSG biopsy Autoantibodies |
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