托特罗定联合萘哌地尔及双氯芬酸钠治疗女性膀胱过度活动症疗效观察

目的 探讨治疗口服托特罗定无效的女性膀胱过度活动症(OAB)的有效方法.方法 选择诊断为OAB且口服托特罗定后无效的20例女性患者,给予口服托特罗定2 mg,2次/d;萘哌地尔25 mg,每晚1次;双氯芬酸钠25 mg,3次/d.用药时间为4周,观察用药前后日平均排尿次数、日平均单次尿量、日单次最大尿量各指标变化.结果 联合治疗前患者日平均排尿次数(19±6)次,日平均单次尿量(106±33)ml,日平均单次最大尿量(155±32)ml;联合治疗后日平均排尿次数(10±4)次,日平均单次尿量(284±74)ml,日平均单次最大尿量(358±82)ml,治疗前后各观察指标比较,差异均有统计学意义(P＜0.05).结论 托特罗定联合萘哌地尔及双氯芬酸钠能够有效改善口服托特罗定无效的女性OAB患者临床症状,提高生活质量.

Abstract：

Objective To explore the effective therapy of feminine overactive bladder of tolterodine invalid.Methods Twenty patients were treated with tolterodine combined with naftopidil and diclofenac sodium. The total therapy lasted 4 weeks. The time of urination per day,the average amount of mona-urination and the maximum amount of mona-urination were observed and the changes of all indexes before and after treatment were assessed.Results Before treatment,the daily mean frequency of urination was (19 ± 6) times,the daily mean single urine volume was (106 ±33)ml and the daily mean maximum urine volume was (284 ±74)ml. After treatment,the daily mean urination frequency was (10 ±4)times,the daily mean single urine volume was (284 ± 74)ml and the daily mean maximum urine volume was(358 ±82)ml. All the indicators showed significant difference between before and after treatment (P ＜ 0.05). Conclusions Tolterodine combined with naftopidil and diclofenac sodium can be an effective method for female overactive bladder of tolterodine invalid.

Tolterodine combined with naftopidil and diclofenac sodium treating feminine overactive bladder of tolterodine invalid

Objective To explore the effective therapy of feminine overactive bladder of tolterodine invalid.Methods Twenty patients were treated with tolterodine combined with naftopidil and diclofenac sodium. The total therapy lasted 4 weeks. The time of urination per day,the average amount of mona-urination and the maximum amount of mona-urination were observed and the changes of all indexes before and after treatment were assessed.Results Before treatment,the daily mean frequency of urination was (19 ± 6) times,the daily mean single urine volume was (106 ±33)ml and the daily mean maximum urine volume was (284 ±74)ml. After treatment,the daily mean urination frequency was (10 ±4)times,the daily mean single urine volume was (284 ± 74)ml and the daily mean maximum urine volume was(358 ±82)ml. All the indicators showed significant difference between before and after treatment (P ＜ 0.05). Conclusions Tolterodine combined with naftopidil and diclofenac sodium can be an effective method for female overactive bladder of tolterodine invalid.